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Matt Lambon-Ralph
Unit Director

Matt.Lambon-Ralph@mrc-cbu.cam.ac.uk
01223 7767754
Research Programme:

Research interests and approach:

1. Semantic cognition and its disorders: various interlinked projects explore the nature and neural underpinnings of semantic memory or conceptual knowledge. Our convergent, multimethod approach is founded in detailed, comparative investigations of semantic dementia, herpes simplex virus encephalitis (HSVE), aphasia after CVA and temporal lobe resection for epilepsy, and is complemented by parallel TMS, fMRI, structural and functional connectivity studies, and cortical-grid explorations.
2. Aphasia: multiple interlocking projects explore the cognitive and neural mechanisms that underpin acquired language impairments (aphasia). These include investigations of fluent and non-fluent varieties of progressive and non-progressive aphasia. Inspired by the patients, we also conduct parallel explorations in healthy participants utilising experimental psycholinguistics, TMS, computational modelling, fMRI, structural and functional connectivity analyses.
3. Recovery, rehabilitation and neuroplasticity: As well as concentrating on the nature of chronic and progressive cognitive and language deficits, the third theme is devoted to the study of the neural and cognitive principles that guide recovery and rehabilitation. This includes active rehabilitation programmes, longitudinal neuropsychological and neuroimaging assessment of recovery, computational models of neuroplasticity and parallel functional imaging studies of patients.

Our research makes parallel use of multiple methodologies in an attempt to secure convergent insights on the given research topic. These include: neuropsychology, computational models (models that can mimic neural organisation in their construction but also produce target behaviours), transcranial magnetic stimulation (TMS), structural and functional neuroimaging, and cortical grid-electrode studies.

Over the years, I have been lucky to work on these topics with many talented early career researchers and collaborators. Current fellows, postdocs and PhDs include:

Dr. Reem Alyahya (King Fahad Medical City sponsored postdoc) – Explorations of verbs and connected speech in aphasia, TMS and fMRI.
Dr. Francesca Branzi (ERC-funded postdoc) – The cognitive and neural bases of combinatorial and event semantics.
Natalie Busby (MRC CASE studentship with Bioxydyn) – Anatomical connectivity maps and their clinical application
Dr. YaNing Chang (ERC-funded postdoc) – Neurocomputational models of aphasia recovery.
Dr. Rocco Chiou (Sir Henry Wellcome Fellow) - Dynamics between frontotemporal language network and sensory cortices in perceiving, recognising, and using objects.
Katherine Gore (MRC NPIF studentship) – Neuroscience-based therapy of word-finding difficulties in post-stroke aphasia.
Dr. Ajay Halai (Rosetrees Trust and ERC-funded postdoc) – Explorations of post stroke aphasia, recovery, rehabilitation and prediction modelling.
Dr. Gina Humphreys (MRC programme-funded postdoc) – Explorations of the inferior parietal cortex in semantics and other cognitive functions.
Ruth Ingram (ERC funded RA/PhD) – Comparison of stroke and primary progressive aphasias.
Dr. Rebecca Jackson (BA postdoctoral fellow) - Developing a full computational account of semantic cognition and its disorders.
Emer Jones (BBSRC DTP studentship) – Improving deep neural networks as a modelling framework for human ventral stream computations.
Dr. Grace Rice (Danish Council for Independent Research postdoc) - The Back of the Brain project (BoB): A new approach to cerebral localisation of perceptual functions.
James Stefaniak (Wellcome N4 Clinical PhD) – Neural compensatory mechanisms that underpin retention and recovery of language function post stroke.
Dr. Ying Zhao (ERC-funded postdoc) – Multivariate analyses of multimodal neuroimaging in post-stroke aphasia.

Biography:

I obtained my PhD from York University and then worked at the MRC Cognition and Brain Sciences Unit (Cambridge). I moved from there to the University of Bristol, Department of Experimental Psychology, as a Lecturer. I went to Manchester in 2001 as Professor of Cognitive Neuroscience within the School of Psychological Sciences, where I also became Associate Vice-President (Research) and Director of the Manchester Doctoral College. In 2018, I had the honour of being appointed as the Director of the MRC Cognition and Brain Sciences Unit.

I am an action editor for Neurobiology of Language, and Neuropsychological Rehabilitation. I am on the editorial boards for Cognitive NeuropsychologyMemory, International Journal of Language & Communication Disorders, Alzheimer's Research & Therapy, Psychologia, and Neurocase. I was the President of The British Neuropsychological Society (2010-12) and the Vice-Chair for the British Aphasiology Society (2000-2005). I was made a Fellow (hons) of the Royal College of Speech and Language Therapists in 2003, Fellow of the British Psychological Society in 2012 and Fellow of the Academy of Medical Sciences in 2019. I am also Honorary Research Professor of the University of Málaga in 2014 and a Senior Investigator Emeritus for the NIHR. I was awarded the BPS President's Award in 2015, the Barbara Newcombe (mid-career) Prize by the British Neuropsychological Society in 2016, the Mid-Career Award by the British Association for Cognitive Neuroscience in 2016, and the 17th Mid-Career Award by the Experimental Psychology Society in 2018. I am currently the chair of the EU Human Brain Project Stakeholder Board (the principal oversight committee).

CBSU publications
CHIOU, R., LAMBO N-RALPH, M. (In Press) Unveiling the dynamic interplay between the hub and spoke-components of the brain’s semantic system and its impact on human behaviour, NeuroImage [Read More]

JACKSON, R., Baj ada, C., LAMBON-RALPH, M. & Cloutman, L (In Press) The graded change in connectivity across the ventromedial prefrontal cortex reveals distinct subregions, Cerebral Cortex [Read More]

HOLLAND, R., Lam bon Ralph, M.A. (2010) The anterior temporal lobe semantic hub is a part of the language neural network: Selective disruption of irregular past tense verbs by rTMS, Cerebral Cortex, 20(12), 2771-2775 [Open Access]

Jefferies, E., P ATTERSON, K., Jones, R.W., Lambon Ralph, M.A. (2009) Comprehension of Concrete and Abstract Words in Semantic Dementia, Neuropsychology, 23(4), 492-499 [Read More]

Fushimi, T., Kom ori, K., Ikeda, M., Lambon-Ralph, M.A. & PATTERSON, K. (2009) The association between semantic dementia and surface dyslexia in Japanese, Neuropsychologia, 47(4), 1061-1068 [Read More]

Lambon Ralph, M. A. & PATTERSON, K. (2008) Generalisation and differentiation in semantic memory: Insights from semantic dementia, Annals of the New York Academy of Sciences, 1124, 61-76 [Open Access]

Jefferies, E., P ATTERSON, K. & Lambon Ralph, M.A. (2008) Deficits of knowledge versus executive control in semantic cognition: Insights from cued naming, Neuropsychologia, 46(2), 649-658 [Read More]

PATTERSON, K., G RAHAM, N.L., Lambon Ralph, M.A. & HODGES, J.R. (2008) Varieties of silence: The impact of neurodegenerative diseases on language systems in the brain., In J.R. Pomerantz & M Crair (Eds), Topics in Integrative Neuroscience: from Cells to Cognition [Read More]

WOOLLAMS, A.M., Lambon Ralph, M.A., Plaut, D.C & PATTERSON, K. (2007) SD-Squared: On the association between semantic dementia and surface dyselxia, Psychological Review, 114(2), 316-339 [Read More]

Jefferies, E., P ATTERSON, K. & Lambon Ralph, M.A. (2006) The natural history of late-stage “pure” semantic dementia, Neurocase, 12(1), 1-14 [Read More]

Ikeda, M., PATTE RSON, K., GRAHAM, K.S., Lambon Ralph, M.A. & HODGES, J.R. (2006) “A horse of a different colour”. Do patients with semantic dementia recognise different versions of the same object as the same?, Neuropsychologia, 44(4), 566-575 [Read More]

PATTERSON, K., L ambon Ralph, M.A., Jefferies, E., WOOLLAMS, A., Jones, R., HODGES, J.R. & ROGERS, T.T. (2006) ‘Pre-semantic’ cognition in semantic dementia: Six deficits in search of an explanation, Journal of Cognitive Neuroscience, 18(2), 169-183 [Read More]

PATTERSON, K., G RAHAM, N.L., Lambon Ralph, M.A. & HODGES, J.R. (2006) Progressive non-fluent aphasia is not a progressive form of non-fluent (post-stroke) aphasia, Aphasiology, 20(9-11), 1018-1034 [Read More]

Mechelli, A., Cr inion, J., Long, S., Friston, K.J., Lambon Ralph, M.A., PATTERSON, K., Mcclelland, J.L. & Price, C.J. (2005) Dissociating reading processes on the basis of neuronal interactions, Journal of Cognitive Neuroscience, 17(11), 1753-1765 [Read More]

Lambon Ralph, M. A., Braber, N., Mcclelland, J.L. & PATTERSON, K. (2005) What underlies the neuropsychological pattern of irregular > regular past-tense verb production?, Brain and Language, 93(1), 106-119 [Read More]

Braber, N., PATT ERSON, K., Ellis, K. & Lambon Ralph, M. (2005) The relationship between phonological and morphological deficits in Broca’s aphasia: Further evidence from errors in verb inflection, Brain and Language, 92(3), 278-287 [Read More]

Garrard, P., Lam bon Ralph, M., PATTERSON, K., PRATT, K.H. & HODGES, J.R. (2005) Semantic feature knowledge and picture naming in dementia of Alzheimer’s type: A new approach, Brain and Language, 93(1), 79-94 [Read More]

Jefferies, E., L ambon Ralph, M.A., Jones, R., Bateman, D. & PATTERSON, K. (2004) Surface dyslexia in semantic dementia: A comparison of the influence of consistency and regularity, Neurocase, 10(4), 290-299 [Read More]

Jefferies, E., P ATTERSON, K., Jones, R.W., Bateman, D. & Lambon Ralph, M.A. (2004) A category-specific advantage for numbers in verbal short-term memory: Evidence from semantic dementia, Neuropsychologia, 42(5), 639-660 [Read More]

ROGERS, T.T., La mbon Ralph, M.A., Garrard, P., BOZEAT, S., McClelland, J.L., HODGES, J.R. & PATTERSON, K. (2004) The structure and deterioration of semantic memory: A neuropsychological and computational investigation, Psychological Review, 111(1), 205-235 [Read More]

ROGERS, T.T., La mbon Ralph, M.A., HODGES, J.R. & PATTERSON, K. (2004) Natural Selection: The impact of semantic impairment on lexical and object decision, Cognitive Neuropsychology, March 2004, 21(2-3-4), 331-352 [Read More]

BIRD, H., Lambon Ralph, M.A., Seidenberg, M.S., McClelland, J.L., & PATTERSON, K. (2003) Deficits in phonology and past-tense morphology: What’s the connection?, Journal of Memory and Language, 48(3), 502-526 [Read More]

ROGERS, T.T., La mbon Ralph, M.A., HODGES, J. & PATTERSON, K. (2003) Object recognition under semantic impairment: The effects of conceptual regularities on perceptual decisions , Language and Cognitive Processes, 18(5-6), 625-662 [Read More]

Lambon Ralph, M. A., PATTERSON, K., Garrard , P. & HODGES, J.R. (2003) Semantic dementia with category specificity: A comparative case-series study, Cognitive Neuropsychology, 20(3-4-5-6), 307-326 [Read More]

BOZEAT, S., Lamb on Ralph, M.A., GRAHAM, K.S., PATTERSON, K., Wilkin, H., Rowland, J., ROGERS , T.T. & HODGES, J.R. (2003) A Duck with Four Legs: Investigating the Structure of Conceptual Knowledge using Picture Drawing in Semantic Dementia, Cognitive Neuropsychology 20(1), 27-47 [Read More]

ROGERS, T. T., L ambon Ralph, M.A, HODGES, J.R, and PATTERSON, K (2002) When recognition is dominated by regularity: The effects of semantic impairment on perceptual decisions., In: Cognitive Neuroscience Society Annual Meeting Program 2002. [Read More]

ROGERS,T.T., Lam bon Ralph, M.A., Plaut, D.C., HODGES, J.R. & PATTERSON, K. (2002) Domain differences in semantic dementia: Implications for theories of category-specific deficits., In Proceedings of the 2002 Experimental Psychology Conference, Leuven, Belgium, April 2002, S7.1 [Read More]

ROGERS, T.T.R., Lambon Ralph, M.A., HODGES, J.R. & PATTERSON, K. (2002) When recognition is dominated by regularity: The effects of conceptual regularities on perceptual and lexical decisions., In Proceedings of the 9th annual meeting of the Cognitive Neuroscience Society, San Farncisco, California, April 2002, 108 [Read More]

BOZEAT, S., Lamb on Ralph, M.A., PATTERSON, K.& HODGES, J.R. (2002) When objects lose their meaning: What happens to their use?, Cognitive, Affective, & Behavioral Neurosciences, 2002, 2, 236-251. [Read More]

Garrard, P., Lam bon-Ralph, M.A. & HODGES, J.R. (2002) Semantic Dementia. A category-specific paradox., Forde & Humphreys (Eds) Category-specificity in brain and mind, Psychology Press 149-179 [Read More]

BOZEAT, S., Lamb on Ralph, M.A., PATTERSON, K.P. & HODGES, J.R. (2002) The Influence of Personal Familiarity and Context on Object Use in Semantic Dementia, Neurocase, 8, 127-134 [Read More]

ROGERS, T.T., La mbon Ralph, M.A., HODGES, J.R., & PATTERSON, K (2001) When recognition is dominated by regularity: Perceptual and lexical decisions under semantic impairment, Abstracts of the Psychonomic Society, 6, 74-75 [Read More]

ROGERS, T.T.R., Lambon Ralph, M.A., HODGES, J.R. & PATTERSON, K. (2001) Object recognition under semantic impairment: The effects of conceptual regularities on perceptual decisions., In Proceedings of the 42nd annual meeting of the Psychonomic Society, Orlando, Florida, November 2001. [Read More]

PATTERSON, K., L ambon Ralph, M.A., HODGES, J.R. & McClelland, J.L. (2001) Deficits in irregular past-tense verb morphology associated with degraded semantic knowledge, Neuropsychologia, 39 (7), 709-724 [Read More]

Galton, C.J., PA TTERSON, K., GRAHAM, K., Lambon Ralph, M.A., Williams. G., Antoun, N., Sahakian, B.& HODGES, J.R. (2001) Differing patterns of temporal lobe atrophy in Alzheimer’s disease and semantic dementia., Neurology, 57, 216-225 [Read More]

Garrard, P., Lam bon Ralph, M.A., Watson, P.C., Powis, J., PATTERSON, K. & HODGES, J.R. (2001) Longitudinal profiles of semantic impairment for living and nonliving concepts in dementia of Alzheimer’s type., Journal of Cognitive Neuroscience, 13 (7) 892-909 [Read More]

Lambon Ralph, M. A., Powell, J., Howard, D., Whitworth, A.B., Garrard, P. & HODGES, J.R. (2001) Semantic memory is impaired in both dementia with Lewy bodies and dementia of Alzheimer’s type: a comparative neuropsychological study and literature review, Journal of Neurology, Neurosurgery & Psychiatry, 70, 149-156 [Read More]

Garrard, P., Lam bon Ralph, M.A., HODGES, J.R. & PATTERSON, K. (2001) Prototypicality, distinctiveness, and intercorrelation: analyses of the semantic attributes of living and nonliving concepts, Cognitive Neuropsychology, 18 (2), 125-174 [Read More]

LAMBON RALPH, M. A., Mcclelland, J.L., PATTERSON, K., Galton, C.J. & HODGES, J.R. (2001) No right to speak? The relationship between object naming and semantic impairment: Neuropsychological evidence and a computational model, Journal of Cognitive Neuroscience, 13 (3), 341-356 [Read More]

LAMBON-RALPH, M. A., & GRAHAM, N.L (2000) Mini Review – Previous cases: Acquired phonological and deep dyslexia, Neurocase, 6, 141-178 [Read More]

Lambon Ralph, M. A., Mcclelland, J.L., PATTERSON, K. & HODGES, J.R. (2000) The relationship between semantic memory and speech production: Neuropsychology, neuroanatomy, and a neural-net model, Higher Brain Function Research (Shitsugosho Kenkyu), 20 (2) 145-156 [Read More]

Patterson, K., L ambon Ralph, M. A., Bird, H., Hodges, J R., McClelland, J.L. (2000) Normal and Impaired Processing in Quasi-Regular Domains of Lanuage: The Case Of English Past-Tense Verbs, Proceedings of the 6th International Conference on Spoken Language Processing, Vol 2, Beijing, China, 15-19 [Read More]

BIRD, H.E., LAMB ON RALPH, M.A., PATTERSON, K. & HODGES, J.R. (2000) The Rise and Fall of Frequency and Imageability: Noun and Verb Production in Semantic Dementia , Brain and Language, 73(1), 17-49 [Read More]

LAMBON RALPH, M. A. & GRAHAM, N.L. (2000) Acquired phonological and deep dyslexia., Neurocase, 2000, 6(2), 141-178 [Read More]

BOZEAT, S., LAMB ON RALPH, M.A., PATTERSON, K., Garrard, P. & HODGES, J.R. (2000) Non-verbal semantic impairment in semantic dementia, Neuropsychologia 2000, 38 (9), 1207-1215 [Read More]

Ellis, A.W. & LA MBON RALPH, M.A. (2000) Age of acquisition effects in adult lexical processing reflect loss of plasticity in maturing systems: insights from connectionist networks. , Journal of Experimental Psychology: Learning, Memory and Cognition, 26(5), 1103-1123. [Read More]

BOZEAT, S., Greg ory, C.A., LAMBON RALPH, M.A. & HODGES , J.R. (2000) Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer’s disease, Journal of Neurology, Neurosurgery & Psychiatry 2000; 69; 178-186 [Read More]

Ellis, A.W., LAM BON RALPH, M.A., Morris, J. & Hunter, A. (2000) Surface dyslexia: Description, treatment, and interpretation, In E. Funnell (Ed.) “Case studies in the neuropsychology of reading” Psychology Press: Hove, UK. (2000) [Read More]

LAMBON RALPH, M. A., Sage, K. & Roberts, J. (2000) Classical anomia: a neuropsychological perspective on speech production, Neuropsychologia, 2000, 38, 186-202. [Read More]

Lambon Ralph, M. A. and Howard, D. (2000) Gogi aphasia or semantic dementia? Assessing poor verbal comprehension in a case of fluent progressive aphasia, Cognitive Neuropsychology 17(5), 437-465 [Read More]

Lambon Ralph, M. A., Graham, K.S., Patterson, K. & Hodges, J.R. (1999) Is a picture worth a thousand words? Evidence from concept definitions by patients with semantic dementia., Brain and Language, 1999, 70, 309-335. [Read More]

Simons J.S. & La mbon Ralph, M.A. (1999) The auditory agnosias., Neurocase, 1999, 5, 379-406. [Read More]

PATTERSON, K. & LAMBON RALPH, M.A. (1999) Selective disorders of reading? , Current Opinion in Neurobiology (1999), 9 (2), 235-239. [Read More]

GRAHAM, K.S., LA MBON RALPH, M. & HODGES, J.R (1999) A questionable semantics: the interactions between semantic knowledge and autobiographical experience in semantic dementia. , Cognitive Neuropsychology, 1999, 16(7), 689-698 [Read More]

LAMBON RALPH, M. A., Cipolotti, L., & PATTERSON, K. (1999) Oral naming and oral reading: do they speak the same language?, Cognitive Neuropsychology, 16(2), 157-169 [Read More]

LAMBON RALPH, M. A., Ellis, A.W. and Sage, K. (1998) Word meaning blindness revisited., Cognitive Neuropsychology, 1998, 15 (4), 389-400. [Read More]

LAMBON RALPH, M. A., GRAHAM, K.S., Ellis, A.W. & HODGES, J.R. (1998) Naming in semantic dementia – what matters?, Neuropsychologia (1998) 36 (8), 775-784. [Read More]

LAMBON RALPH, M. A., Howard, D., Nightingale, G. & Ellis, A.W. (1998) Are living and non-living category-specific deficits causally linked to impaired perceptual or associative knowledge? Evidence from a category-specific double dissociation., Neurocase (1998), 4, 311-338. [Read More]

LAMBON RALPH, M. A., JARVIS, C., ELLIS, A.W. (1997) Life in a mirrored world: Report of a case showing mirror reversal in reading and writing and for non-verbal materials, Neurocase 1997, 3 (4), 249-258 [Read More]

LAMBON RALPH, M. A. & Ellis, A.W. (1997) “Patterns of paralexia” revisited: Report of a case of visual dyslexia., Cognitive Neuropsychology, 14, 953-974. [Read More]

GRAHAM, K.S., La mbon Ralph, M.A. & HODGES, J.R. (1997) Determining the impact of autobiographical experience on “Meaning”: New insights from investigating sports-related vocabulary and knowledge in two cases with semantic dementia., Cognitive Neuropsychology, 14, 801-837. [Read More]

Lambon Ralph, M. , PATTERSON, K. & HODGES, J. (1997) The relationship between naming and semantic knowledge for different categories in dementia of Alzheimer’s type., Neuropsychologia, 35, 1251-1260 [Read More]

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