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Data Repository


This page shows all 150 data sets currently available in our Data repository

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Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences
Authors:
Liu, K.Y., KIEVIT, R.A., Tsvetanov, K.A., Betts, M.J., Düzel, E., Rowe, J.B., Cam-CAN*, Howard, R. & Hämmerer, D.
Reference:
Nature Communications, 11(1):1712
Year of publication:
2020
CBU number:
8510
Abstract:
The locus coeruleus (LC), the origin of noradrenergic modulation of cognitive and behavioral function, may play an important role healthy ageing and in neurodegenerative conditions. We investigated the functional significance of age-related differences in mean normalized LC signal intensity values (LC-CR) in magnetization-transfer (MT) images from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort - an open-access, population-based dataset. Using structural equation modelling, we tested the pre-registered hypothesis that putatively noradrenergic (NA)-dependent functions would be more strongly associated with LC-CR in older versus younger adults. A unidimensional model (within which LC-CR related to a single factor representing all cognitive and behavioral measures) was a better fit with the data than the a priori two-factor model (within which LC-CR related to separate NAdependent and NA-independent factors). Our findings support the concept that age-related reduction of LC structural integrity is associated with impaired cognitive and behavioral function.
URL:
Data available, click to request
Contributions of working memory and inhibition to cognitive flexibility in Nigerian adolescents
Authors:
NWEZE, T., Nwani, W.
Reference:
Developmental Neuropsychology
Year of publication:
In Press
CBU number:
8506
Abstract:
This study used a novel approach that combined the latency and accuracy scores to examine the relative involvement of inhibition and working memory in two measures of cognitive flexibility – mixing cost and switch cost in 110 Nigerian adolescents. Results showed that inhibition was significantly associated with switch cost. On the other hand, working memory was negatively associated with mixing cost. These findings support the assumptions that cognitive flexibility skills are dependent on inputs from inhibition and working memory processes. Inhibition is involved in the deactivation of irrelevant stimuli during switching trials while working memory is essential to maintain the current rule in sets that require no shifting. Pre-Print link: https://psyarxiv.com/m2zsg/
Data available, click to request
A Domain-General Cognitive Core Defined in Multimodally Parcellated Human Cortex
Authors:
ASSEM, M., Glasser, M.F., Van Essen, D.C., DUNCAN, J.D.
Reference:
Cerebral Cortex
Year of publication:
In Press
CBU number:
8505
Abstract:
Numerous brain imaging studies identified a domain-general or “multiple-demand” (MD) activation pattern accompanying many tasks and may play a core role in cognitive control. Though this finding is well established, the limited spatial localization provided by traditional imaging methods precluded a consensus regarding the precise anatomy, functional differentiation, and connectivity of the MD system. To address these limitations, we used data from 449 subjects from the Human Connectome Project, with the cortex of each individual parcellated using neurobiologically grounded multimodal MRI features. The conjunction of three cognitive contrasts reveals a core of 10 widely distributed MD parcels per hemisphere that are most strongly activated and functionally interconnected, surrounded by a penumbra of 17 additional areas. Outside cerebral cortex, MD activation is most prominent in the caudate and cerebellum. Comparison with canonical resting-state networks shows MD regions concentrated in the fronto-parietal network but also engaging three other networks. MD activations show modest relative task preferences accompanying strong co-recruitment. With distributed anatomical organization, mosaic functional preferences, and strong interconnectivity, we suggest MD regions are well positioned to integrate and assemble the diverse components of cognitive operations. Our precise delineation of MD regions provides a basis for refined analyses of their functions.
URL:
Data available, click to request
Evaluating the granularity and statistical structure of lesions and behaviour in post-stroke aphasia
Authors:
ZHAO, Y., HALAI, A., LAMBON RALPH, M.A.
Reference:
Brain Communications
Year of publication:
In Press
CBU number:
8501
Abstract:
The pursuit of relating the location of neural damage to the pattern of acquired language and general cognitive deficits post-stroke stems back to 19th century behavioural neurology. Whilst spatial specificity has improved dramatically over time, from the large areas of damage specified by post-mortem investigation to the millimetre precision of modern MRI, there is an underlying issue that is rarely addressed, which relates to the fact that damage to a given area of the brain is not random but constrained by the brain’s vasculature. Accordingly, the aim of this study was to uncover the statistical structure underlying the lesion profile in chronic aphasia post-stroke. By applying varimax-rotated principal component analysis to the lesions of 70 patients with chronic post-stroke aphasia, we identified 17 interpretable clusters, largely reflecting the vascular supply of middle cerebral artery sub-branches and other sources of individual variation in vascular supply as shown in classical angiography studies. This vascular parcellation produced smaller displacement error in simulated lesion-symptom analysis compared with individual voxels and Brodmann regions. A second principal component analysis of the patients’ detailed neuropsychological data revealed a four factor solution reflecting phonological, semantic, executive-demand and speech fluency abilities. As a preliminary exploration, stepwise regression was used to relate behavioural factor scores to the lesion principal components. Phonological ability was related to two components, which covered the posterior temporal region including the posterior segment of the arcuate fasciculus, and the inferior frontal gyrus. Three components were linked to semantic ability and were located in the white matter underlying the anterior temporal lobe, the supramarginal gyrus and angular gyrus. Executive-demand related to two components covering the dorsal edge of the middle cerebral artery territory, while speech fluency was linked to two components that were located in the middle frontal gyrus, precentral gyrus, and subcortical regions (putamen and thalamus). Future studies can explore in formal terms the utility of these PCA-derived lesion components for relating post-stroke lesions and symptoms. Preprint link: http://europepmc.org/article/PPR/PPR98746
Data available, click to request
Evidence for prereg posters as a platform for preregistration
Authors:
Brouwers, K., Cooke, A., Chambers, C.D., HENSON, R.N.A., & TIBON, R.
Reference:
Nature Human Behaviour
Year of publication:
In Press
CBU number:
8499
Abstract:
Prereg posters are conference posters that present planned scientific projects. We provide preliminary evidence for their value in receiving constructive feedback, promoting open science, and supporting early career researchers. Preprint link: https://www.biorxiv.org/content/10.1101/833640v2
Data available, click to request
Working for the future: Parentally deprived Nigerian Children have enhanced working memory ability
Authors:
NWEZE, T., Nwoke, M.B., Nwufo, J.I., Aniekwu, R.I., Lange,F.
Reference:
Journal of Child Psychology and Psychiatry
Year of publication:
In Press
CBU number:
8482
Abstract:
Background: The dominant view based on the deficit model of developmental psychopathology is that early adverse rearing impairs cognition. In contrast, an emerging evolutionary-developmental model argues that individuals exposed to early life stress may have improved cognitive abilities that are adapted to harsh environments. We set out to test this hypothesis by examining cognitive functions in parentally deprived children in Nigeria. Methods: Cognitive performance was compared between 53 deprived children who currently live in institutional homes and foster families and 51 non-deprived control participants. We used a multifaceted neurocognitive test battery for the assessment of inhibition, set shifting, and working memory. Results: Results showed that the deprived and non-deprived group did not significantly differ in their performance on set-shifting and inhibition tasks. Conversely, the deprived group performed significantly better than the non-deprived group in the working memory task. Discussion: We interpret the enhanced working memory ability of the deprived group as a correlate of its ecological relevance. In Nigeria, underprivileged children may need to rely to a larger extent on working memory abilities to attain success through academic work. This study provides further evidence that exposure to early adversity does not necessarily impair cognitive functions but can even enhance it under some conditions and in some domains.
URL:
Data available, click to request
Improved motion correction of submillimetre 7T fMRI time series with boundary-based registration (BBR)
Authors:
HUANG, PEI., CARLIN, J.D., HENSON, R.N., CORREIA, M.M.
Reference:
Neuroimage, Volume 210, 15 April 2020, 116542
Year of publication:
2020
CBU number:
8464
URL:
Data available, click to request
Focused Representation of Successive Task Episodes in Frontal and Parietal Cortex
Authors:
Kadohisa, M., Watanabe, K., Kusunoki,M., Buckley, M.JK., DUNCAN, J.D.
Reference:
Cerebral Cortex, bhz202
Year of publication:
2019
CBU number:
8458
URL:
Data available, click to request
Efficiency in Magnocellular Processing: A Common Deficit in Neurodevelopmental Disorders
Authors:
BROWN, A., Peters, J., Parsons, C., Crewther, D. and Crewther, S.
Reference:
Frontiers in Human Neuroscience (Sensory Neuroscience)
Year of publication:
In Press
CBU number:
8441
Abstract:
Several neurodevelopmental disorders (NDDs) including Developmental Dyslexia (DD), Autism Spectrum Disorder (ASD), but not Attention Deficit Hyperactive Disorder (ADHD), are reported to show deficits in global motion processing. Such behavioral deficits have been linked to a temporal processing deficiency. However, to date, there have been few studies assessing the temporal processing efficiency of the Magnocellular M pathways through temporal modulation. Hence, we measured achromatic flicker fusion thresholds at high and low contrast in nonselective samples of NDDs and neurotypicals (mean age 10, range 7–12 years, n = 71) individually, and group matched, for both chronological age and nonverbal intelligence. Autistic tendencies were also measured using the Autism-Spectrum Quotient questionnaire as high AQ scores have previously been associated with the greater physiological amplitude of M-generated nonlinearities. The NDD participants presented with singular or comorbid combinations of DD, ASD, and ADHD. The results showed that ASD and DD, including those with comorbid ADHD, demonstrated significantly lower flicker fusion thresholds (FFTs) than their matched controls. Participants with a singular diagnosis of ADHD did not differ from controls in the FFTs. Overall, the entire NDD plus control populations showed a significant negative correlation between FFT and AQ scores (r = −0.269, p < 0.02 n = 71). In conclusion, this study presents evidence showing that a temporally inefficient M pathway could be the unifying network at fault across the NDDs and particularly in ASD and DD diagnoses, but not in singular diagnosis of ADHD
Data available, click to request
Apathy is associated with reduced precision of prior beliefs about action outcomes
Authors:
HEZEMANS, F.H., Wolpe, N., ROWE, J.B.
Reference:
Journal of Experimental Psychology: General
Year of publication:
In Press
CBU number:
8437
Data available, click to request


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