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Our publication database contains 7781 publications dating back to 1943. You can browse some of the most recently added entries below, or you can:

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Recently Added Publications


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Using in-vivo functional and structural connectivity to predict chronic stroke aphasia deficits
Authors:
HALAI, A., Zhao, Y., Cox, C., LAMBON RALPH, M.
Reference:
Brain
Year of publication:
In Press
CBU number:
8894
Abstract:
Focal brain damage caused by stroke can result in aphasia and advances in cognitive neuroscience suggest that impairment may be associated with network-level disorder rather than just circumscribed cortical damage. A number of studies have shown meaningful relationships between brain-behaviour using lesions; however only a handful of studies have incorporated in-vivo structural and functional connectivity. Patients with chronic post-stroke aphasia were assessed with structural (N=68) and functional (N=39) MRI to assess whether predicting performance can be improved with multiple modalities and if additional variance can be explained compared to lesion models alone. These neural measurements were used to construct models to predict four key language-cognitive factors: 1) phonology, 2) semantics, 3) executive function, and 4) fluency. Our results showed that each factor (except executive ability) could be significantly related to each neural measurement alone; however, structural and functional connectivity models did not explain additional variance above the lesion models. We did find evidence that the structural and functional predictors may be linked to the core lesion sites. First, the predictive functional connectivity features were found to be located within functional resting state networks identified in healthy controls, suggesting that the result might reflect functionally-specific reorganisation (damage to a node within a network can result in disruption to the entire network). Second, predictive structural connectivity features were located within core lesion sites, suggesting that multi-modal information may be redundant in prediction modelling. In addition, we observed that the optimum sparsity within the regularised regression models differed for each behavioural component and across different imaging features, suggesting that future studies should consider optimising hyperparameters related to sparsity per target. Together, the results indicate that the observed network-level disruption was predicted by the lesion alone and does not significantly improve model performance in predicting the profile of language impairment.
On the role of inhibition in suppression-induced forgetting.
Authors:
VAN SCHIE, K., Fawcett, J.M., ANDERSON, M.C.
Reference:
Scientific Reports, 13(1), 4242
Year of publication:
2023
CBU number:
8893
Abstract:
Suppressing retrieval of unwanted memories can cause forgetting, an outcome often attributed to the recruitment of inhibitory control. This suppression-induced forgetting (SIF) generalizes to different cues used to test the suppressed content (cue-independence), a property taken as consistent with inhibition. But does cue-independent forgetting necessarily imply that a memory has been inhibited? Tomlinson et al. (Proc Natl Acad Sci 106:15588–15593, 2009) reported a surprising finding that pressing a button also led to cue-independent forgetting, which was taken as support for an alternative interference account. Here we investigated the role of inhibition in forgetting due to retrieval suppression and pressing buttons. We modified Tomlinson et al.’s procedure to examine an unusual feature they introduced that may have caused memory inhibition effects in their experiment: the omission of explicit task-cues. When tasks were uncued, we replicated the button-press forgetting effect; but when cued, pressing buttons caused no forgetting. Moreover, button-press forgetting partially reflects output-interference effects at test and not a lasting effect of interference. In contrast, SIF occurred regardless of these procedural changes. Collectively, these findings indicate that simply pressing a button does not induce forgetting, on its own, without confounding factors that introduce inhibition into the task and that inhibition likely underlies SIF.
URL:
Systematic evaluation of high level visual deficits and lesions in posterior cerebral artery stroke
Authors:
Robotham, R.J., RICE, G.E., Leff, A.P., LAMBON RALPH, M.A., Starrfelt, R.
Reference:
Brain Communications, 5(2), fcad050
Year of publication:
2023
CBU number:
8892
Abstract:
Knowledge about the consequences of stroke on high level vision comes primarily from single case studies of patients selected based on their behavioural profiles, typically patients with specific stroke syndromes like pure alexia or prosopagnosia. There are, however, no systematic, detailed, large-scale evaluations of the more typical clinical behavioural and lesion profiles of impairments in high-level vision after posterior cerebral artery (PCA) stroke. We present behavioural and lesion data from the Back of the Brain (BoB) project, to date the largest (N=64) and most detailed examination of patients with cortical PCA strokes selected based on lesion location. The aim of the current study was to relate behavioural performance with faces, objects and written words to lesion data through two complementary analyses: (1) a multivariate multiple regression analysis to establish the relationships between lesion volume, lesion laterality, and the presence of a bilateral lesion with performance; and, (2) a voxel-based correlational method (VBCM) analysis to establish whether there are distinct or separate regions within the PCA territory that underpin the visual processing of words, faces, and objects. Behaviourally, most patients showed more general deficits in high level vision (n=22) or no deficits at all (n=21). Category-selective deficits were rare (n=6), and were only found for words. Overall, total lesion volume was most strongly related to performance across all three domains. While behavioural impairment in all domains was observed following unilateral left and right as well as bilateral lesions, the regions most strongly related to performance mainly confirmed the pattern reported in more selective cases. For words, these included a left hemisphere cluster extending from the occipital pole along the fusiform and lingual gyri; for objects bilateral clusters which overlapped with the word cluster in the left occipital lobe. Face performance mainly correlated with a right hemisphere cluster within the white matter, partly overlapping with the object cluster. While the findings provide partial support for the relative laterality of posterior brain regions supporting reading and face processing, the results suggest that both hemispheres are involved in the visual processing of faces, words and objects.
URL:
Data available, click to request
A deep hierarchy of predictions enable on-line meaning extraction in a computational model of human speech comprehension.
Authors:
Su, Y., MACGREGOR, L., Olasagasti, Giraud, A-L
Reference:
PLoS Biology
Year of publication:
In Press
CBU number:
8891
Abstract:
Understanding speech requires mapping fleeting and often ambiguous soundwaves to meaning. While humans are known to exploit their capacity to contextualize to facilitate this process, how internal knowledge is deployed on-line remains an open question. Here, we present a model that extracts multiple levels of information from continuous speech online. The model applies linguistic and nonlinguistic knowledge to speech processing, by periodically generating top-down predictions and incorporating bottom-up incoming evidence in a nested temporal hierarchy. We show that a nonlinguistic context level provides semantic predictions informed by sensory inputs, which are crucial for disambiguating among multiple meanings of the same word. The explicit knowledge hierarchy of the model enables a more holistic account of the neurophysiological responses to speech compared to using lexical predictions generated by a neural-network language model (GPT-2). We also show that hierarchical predictions reduce peripheral processing via minimizing uncertainty and prediction error. With this proof-of-concept model we demonstrate that the deployment of hierarchical predictions is a possible strategy for the brain to dynamically utilize structured knowledge and make sense of the speech input. Summary data used in figures are available at https://osf.io/qvghf/ . MATLAB code for the model can be found at https://github.com/suyaqing/hierarchical-speech
Data available, click to request
Lifespan differences in visual short-term memory load-modulated functional connectivity
Authors:
Lugtmeijerm, S., Geerligs, L., Tsvetanov, K.A., MITCHELL, D.J., Cam-Can, Campbell, K.L.
Reference:
Neuroimage, 26 Feb 2023, 270:119982
Year of publication:
2023
CBU number:
8890
Abstract:
Working memory is critical to higher-order executive processes and declines throughout the adult lifespan. However, our understanding of the neural mechanisms underlying this decline is limited. Recent work suggests that functional connectivity between frontal control and posterior visual regions may be critical, but examinations of age differences therein have been limited to a small set of brain regions and extreme group designs (i.e., comparing young and older adults). In this study, we build on previous research by using a lifespan cohort and a whole-brain approach to investigate working memory load-modulated functional connectivity in relation to age and performance. The article reports on analysis of the Cambridge center for Ageing and Neuroscience (Cam-CAN) data. Participants from a population-based lifespan cohort (N = 101, age 23–86) performed a visual short-term memory task during functional magnetic resonance imaging. Visual short-term memory was measured with a delayed recall task for visual motion with three different loads. Whole-brain load-modulated functional connectivity was estimated using psychophysiological interactions in a hundred regions of interest, sorted into seven networks (Schaefer et al., 2018, Yeo et al., 2011). Results showed that load-modulated functional connectivity was strongest within the dorsal attention and visual networks during encoding and maintenance. With increasing age, load-modulated functional connectivity strength decreased throughout the cortex. Whole-brain analyses for the relation between connectivity and behavior were non-significant. Our results give additional support to the sensory recruitment model of working memory. We also demonstrate the widespread negative impact of age on the modulation of functional connectivity by working memory load. Older adults might already be close to ceiling in terms of their neural resources at the lowest load and therefore less able to further increase connectivity with increasing task demands.
Data for this project is available at: https://osf.io/w3s74/
Parental scaffolding during book-sharing predicts child general intelligence
Authors:
DUNCAN, J., Philips, E., MITCHELL, D., Cooper, P., Murray, L.
Reference:
Psychonomic Bulletin and Review
Year of publication:
In Press
CBU number:
8889
Abstract:
While much variance in general intelligence or g is genetic, a substantial environmental component suggests a possible role for parent-child interaction. In particular, previous evidence suggests the importance of parental scaffolding, or provision of cognitive structure to shape child behaviour. A role for scaffolding is consistent with the proposal that, in adult cognition, a critical aspect of g is decomposition of complex problems into a structure of simpler parts. Building on previous work, we recruited 162 parents attending Children’s Centres with a child aged 2-4 years, and examined parental scaffolding during a book-sharing activity. Scaffolding was measured as the first principal component of a variety of parental behaviours, including sensitivity, focusing attention, extending comprehension, and promoting child participation. Child g was measured as the first principal component of a broad cognitive battery, including language, attention, working memory, and executive function. Importantly, we assessed contributions of the parent’s own intelligence, education, and family income. Though these variables were all associated with both child g and parental scaffolding, scaffolding remained predictive of child g even once the influence of these variables was removed. In contrast to the correlation with cognitive proficiency, scaffolding did not predict child pro-social behaviour. We suggest that parental scaffolding supports the child’s development of a broad skill of attentional structuring, promoting the across-the-board cognitive proficiency that is reflected in g.
Verbal fluency tests assess global cognitive status but have limited diagnostic differentiation: Evidence from a large-scale examination of six neurodegenerative diseases
Authors:
HENDERSON, S., Peterson, K.A., PATTERSON, K., LAMBON RALPH, M.A., ROWE, J.B.
Reference:
Brain Communications, 5(2), fcas042
Year of publication:
2023
CBU number:
8888
Abstract:
Verbal fluency is widely used as a clinical test but its utility in differentiating between neurodegenerative dementias and progressive aphasias, and from healthy controls, remains unclear. We assessed whether various measures of fluency performance could differentiate between Alzheimer’s disease, behavioural variant of frontotemporal dementia, non-fluent and semantic variants of primary progressive aphasia, progressive supranuclear palsy, corticobasal syndrome, and healthy controls. Category and letter fluency tasks were administered to 33 controls and 139 patients at their baseline clinical visit. We assessed group differences for total number of words produced, psycholinguistic word properties, and associations between production order and exemplar psycholinguistic properties. Receiver Operating Characteristic curves determined which measure could best discriminate patient groups and controls. Total word count distinguished controls from all patient groups, but neither this measure nor the word properties differentiated the patient groups. Receiver Operating Characteristic curves revealed that, when comparing controls to patients, the strongest discriminators were total word count followed by word frequency. Word frequency was the strongest discriminator for semantic variant of primary progressive aphasia versus other groups. Fluency word counts were associated with global severity as measured by Addenbrooke’s Cognitive Examination-Revised. Verbal fluency is an efficient test for assessing global brain-cognitive health but has limited utility in differentiating between cognitively- and anatomically-disparate patient groups. This outcome is consistent with the fact that verbal fluency requires many different aspects of higher cognition and language.
URL:
Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities
Authors:
King, D.L., HENSON, R.N., KIEVIT, R., Wolpe, N., Brayne, C., Tyler, L., ROWE, J.B., Cam-CAN, Tsvetanov, K.A.
Reference:
Scientific Reports, 13(1):978
Year of publication:
2023
CBU number:
8887
Abstract:
Cardiovascular ageing contributes to cognitive impairment. However, the unique and synergistic contributions of multiple cardiovascular factors to cognitive function remain unclear because they are often condensed into a single composite score or examined in isolation. We hypothesized that vascular risk factors, electrocardiographic features and blood pressure indices reveal multiple latent vascular factors, with independent contributions to cognition. In a population-based deep-phenotyping study (n = 708, age 18–88), path analysis revealed three latent vascular factors dissociating the autonomic nervous system response from two components of blood pressure. These three factors made unique and additive contributions to the variability in crystallized and fluid intelligence. The discrepancy in fluid relative to crystallized intelligence, indicative of cognitive decline, was associated with a latent vascular factor predominantly expressing pulse pressure. This suggests that higher pulse pressure is associated with cognitive decline from expected performance. The effect was stronger in older adults. Controlling pulse pressure may help to preserve cognition, particularly in older adults. Our findings highlight the need to better understand the multifactorial nature of vascular aging. Scripts available here: https://github.com/DebsKing/Distinct_Vascular_Components_relate_To_Cognition Data available here: https://camcan-archive.mrc-cbu.cam.ac.uk/dataaccess
URL:
Data available, click to request
Learning at your brain’s rhythm: individualized entrainment boosts learning for perceptual decisions
Authors:
MICHAEL, E., Covarrubias, L.S., Leong, V., Kourtzi, Z.
Reference:
Cerebral Cortex, 09 Nov 2022, bhac426
Year of publication:
2022
CBU number:
8886
Abstract:
Training is known to improve our ability to make decisions when interacting in complex environments. However, individuals vary in their ability to learn new tasks and acquire new skills in different settings. Here, we test whether this variability in learning ability relates to individual brain oscillatory states. We use a visual flicker paradigm to entrain individuals at their own brain rhythm (i.e. peak alpha frequency) as measured by resting-state electroencephalography (EEG). We demonstrate that this individual frequency-matched brain entrainment results in faster learning in a visual identification task (i.e. detecting targets embedded in background clutter) compared to entrainment that does not match an individual’s alpha frequency. Further, we show that learning is specific to the phase relationship between the entraining flicker and the visual target stimulus. EEG during entrainment showed that individualized alpha entrainment boosts alpha power, induces phase alignment in the pre-stimulus period, and results in shorter latency of early visual evoked potentials, suggesting that brain entrainment facilitates early visual processing to support improved perceptual decisions. These findings suggest that individualized brain entrainment may boost perceptual learning by altering gain control mechanisms in the visual cortex, indicating a key role for individual neural oscillatory states in learning and brain plasticity.
URL:
Data available, click to request
How robustly do multivariate EEG patterns track individual-subject lexico-semantic processing of visual stimuli?
Authors:
PETIT, S., WOOLGAR, A., BROWN, A., Jessen, E.T.,
Reference:
Language, Cognition and Neuroscience
Year of publication:
In Press
CBU number:
8885
Abstract:
Electroencephalography may be a valuable tool for assessing lexico-semantic processing in conditions where behavioural measures are unreliable. Detecting and quantifying effects in individuals is crucial for clinical applications, but individual-subject analyses are frequently not reported, and are hampered by low signal-to-noise. Multivariate analyses (MVPA) may be more sensitive than traditional approaches, so we asked how robustly they could detect differential neural responses to semantically matched and mismatched word/picture pairs in individuals. With clinical application in mind, we compared data from a research-grade EEG system to concurrently recorded data from the wireless Emotiv EPOC+. In both EEG systems, despite robust group-level effects, we only detected statistically significant processing of lexico-semantic condition in 50% of individuals. Surprisingly, detection rates were similar for MVPA and univariate analyses. MVPA may be advantageous when individual responses are heterogeneous, but in this simple paradigm, lexico-semantic processing could not be reliably detected at the individual level.
Data available, click to request


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