skip to primary navigation skip to content

CBSU bibliography search

To request a reprint of a CBSU publication, please click here to send us an email (reprints may not be available for all publications)

Bilateral Activation of the Prefrontal Cortex After Strategic Semantic Cognitive Training
Miotto, E, Savage C., Evans, J., WILSON, B A., Martins, M.G.M., Iaki, S. & Amaro, E
Human Brain Mapping 27(4), 288-295
Year of publication:
CBU number:
The prefrontal cortex (PFC) has been implicated in the ability to apply semantic organizational strategies during verbal encoding and episodic learning. However, there has been no direct evidence demonstrating which specific areas in the PFC are engaged after cognitive training using semantic organizational strategies in healthy adult human subjects. In this study, we investigated the effects of semantic strategic training on brain activity and changes in behavioral performance, after cognitive training, using functional MRI (fMRI). There was a significant activation in bilateral dorsolateral prefrontal (DLPF) and orbitofrontal (OFC) areas after cognitive training. These results demonstrate the engagement of bilateral DLPF and OFC cortex during strategic memory processes, particularly when mobilization and effort of effective use of strategies are required. The functional adaptations observed here may also shed light on some of the processes underlying recovery with cognitive rehabilitation in patient populations with brain injury.