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Multiple-demand regions of human frontal and parietal cortex: function and representational content
Unpublished PhD Thesis, University of Cambridge
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In human magnetic resonance imaging (fMRI), a characteristic pattern of frontal and parietal activity is produced by a wide variety of different cognitive demands including perceptual difficulty, novelty, response conflict, and working memory. Given the generality of this pattern, these regions have been called multiple-demand, or MD, regions. This work explores the function and representational content to the MD regions. Evidence is drawn from neuropsychology (Chapter 2), fMRI with neuropsychological patients (Chapters 3-4), and multi-voxel pattern analysis of fMRI with healthy adults (Chapters 5-7).