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Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives
Authors:
Chamberlain, S.R., Menzies, L.A., HAMPSHIRE, A., Fineberg, N.A., del Campo, N., Craig, K., OWEN, A.M., Bullmore, E.T., Robbins, T.W. & Sahakian. B.J.
Reference:
Science, 321(5887), 421-422.
Year of publication:
2008
CBU number:
6786
Abstract:
Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviors associated with underlying dysregulation of frontostriatal circuitry. Central to neurobiological models of OCD is the orbitofrontal cortex, a neural region that facilitates behavioral flexibility after negative feedback (reversal learning). We identified abnormally reduced activation of several cortical regions, including the lateral orbitofrontal cortex, during reversal learning in OCD patients and their clinically unaffected close relatives, supporting the existence of an underlying previously undiscovered endophenotype for this disorder.
