You are in: Home » Bibliography
CBU bibliography
Go to searchable bibliography index
Heterogenity of Parkinson's disease in the early clinical stages using a data driven approach
| CBU number: | 5843 |
| Authors: | Lewis, S.G.J., Foltynie, T., Blackwell, A.D., Robbins, T.W., OWEN, A.M. & Barker, R.A. |
| Reference: | Journal of Neurosurgery, Neurology and Psychiatry, 76, 343-348 |
| Year of publication: | 2005 |
| Abstract text: | Objective: To investigate the heterogeneity of idiopathic Parkinson's disease (PD) in a data driven manner among a cohort of patients in the early clinical stages of the disease meeting established diagnostic criteria. Methods: Data on demographic, motor, mood, and cognitive measures were collected from 120 consecutive patients in the early stages of PD (Hoehn and Yahr I-III) attending a specialist PD research clinic. Statistical cluster analysis of the data allowed the existence of the patient subgroups generated to be explored. Results: The analysis revealed four main subgroups: (a) patients with a younger disease onset; (b) a tremor dominant subgroup of patients; (c) a non-tremor dominant subgroup with significant levels of cognitive impairment and mild depression; and (d) a subgroup with rapid disease progression but no cognitive impairment. Conclusions: This study complements and extends previous research by using a data driven approach to define the clinical heterogeneity of early PD. The approach adopted in this study for the identification of subgroups of patients within Parkinson's disease has important implications for generating testable hypotheses on defining the heterogeneity of this common condition and its aetiopathological basis and thus its treatment. Previously titled: Defining the clinical heterogeneity of early Parkinsons disease |
| First CBU author: | Owen, A.M |
| Annual report number: | CBUAR 48 |