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Reduced interhemispheric transmission in schizophrenia patients: Evidence from event-related potentials.
Authors:
Endrass, T., MOHR, B. & Rockstroh, B.
Reference:
Neuroscience Letters, 320, 57-60
Year of publication:
2002
CBU number:
5074
Abstract:
Interhemispheric transfer was investigated in 14 schizophrenia patients and 15 age- and sex-matched healthy controls in a lateralized lexical decision task. Words and pseudowords were tachistoscopically presented either to the left (LVF) or to the right visual hemifield (RVF). Event-related potentials (ERP) were determined from 65-channel EEG. Information transfer between hemispheres was assessed by the interhemispheric transmission time (IHTT), the N1-latency difference between ipsilateral and contralateral hemisphere. Controls, but not schizophrenia patients showed significantly faster IHTT from the right to the left hemisphere for words, while IHTT from the left to the right hemisphere did not differ between groups and stimuli. These findings are interpreted in terms of a deficit in schizophrenia to transfer verbal information from the right to the left hemisphere via the corpus callosum.
