My current research interests are on the role of the prefrontal cortex for voluntary and goal directed actions, and prefrontal interactions with other brain systems. I use both MEG and fMRI, along with behavioural and neuropsychological data, to investigate healthy adults and patients with neurodegenerative diseases (such as Parkinson's disease and frontotemporal dementia) and patients with brain lesions (for example due to tumors or stroke). I collaborate with James Rowe and our aim is to understand the cortical networks of the intact brain and to assess changes related to disease.

Please also see profile:

http://www.neuroscience.cam.ac.uk/directory/profile.php?lh01

Journal Articles

Hughes LE, Altena, E, Barker RA, Rowe, JB (2012) Perseveration and Choice in Parkinson's Disease: The Impact of Progressive Frontostriatal Dysfunction on Action Decisions. Cerebral Cortex.

Zhang, J, Hughes, LE, Rowe, JB (2012) Selection and inhibition mechanisms for human voluntary action decisions. Neuroimage, 63(1)392-402.

Rae, CL, Correia, MM, Altena, E, Hughes, LE, Barker, RA, Rowe, JB (2012) White matter pathology in Parkinson's disease: The effect of imaging protocol differences and relevance to executive function. Neuroimage, 62(3) 1675-1684.

Hughes, LE, Nestor, PJ, Hodges, J, Rowe, JB (2011) Magnetoencephalography of frontotemporal dementia: spatiotemporally localised changes during semantic decisions. Brain 134(Pt 9):2513-22.

Perneczky, R, Ghosh, BCP, Hughes, L, Carpenter, RHS, Barker, RA, Rowe, JB. (2011) Saccadic latency in Parkinson's disease correlates with executive function and brain atrophy, but not motor severity. Neurobiol Dis 43(1):79-85

Hughes LE, Barker RA, Owen AM, Rowe JB. (2010) Parkinson's disease and healthy aging: independent and interacting effects on action selection. Journal of Human Brain Mapping; 31(12):1886-99.

Rowe JB, Hughes LE, Nimmo-Smith I. (2010) Action Selection: A race model for selected and non-selected actions distinguishes the contribution of premotor and prefrontal areas to the selection of action. Neuroimage, 51(2):888-96.

Rossell SL, Batty RA, Hughes LE (2010). Impaired semantic memory in the formation and maintenance of delusions post traumatic brain injury: A new cognitive model of delusions. European Archives of Psychiatry and Clinical Neuroscience, 260(8):571-81.

Rowe JB, Hughes L, Barker RA, Owen AM. (2010) Dynamic causal modelling of effective connectivity from fMRI: are results reproducible and sensitive to Parkinson's disease and its treatment? Neuroimage, 52(3):1015-26.

Rowe JB, Hughes L, Williams-Gray CH, Bishop SJ, Fallon S, Barker, RA, Owen, AM (2008) The val158met COMT polymorphism's effect on atrophy in healthy aging and Parkinson's disease. Neurobiology of Aging, 31(6):1064-8.

Rowe J, Hughes L, Eckstein D, Owen AM. (2008) Rule-selection and action-selection have a shared neuroanatomical basis in the human prefrontal and parietal cortex. Cereb Cortex, Oct;18(10):2275-85.

Rowe JB, Hughes L, Ghosh BC, Eckstein D, Williams-Gray CH, Fallon S, Barker RA, Owen AM. (2008) Parkinson's disease and dopaminergic therapy - differential effects on movement, reward and cognition. Brain, 131(Pt 8):2094-105

Hughes LE, Bates TC, Aimola Davies AM (2008) Dissociations in rod bisection: The effect of viewing conditions on perception and action. Cortex, 44(9):1279-87.

Hughes LE, Bates TC, Aimola Davies A (2005) The effects of global and local processing demands on perception and action. Brain and Cognition, 59(1) 71-81.

Hughes LE, Bates TC, Aimola Davies A (2004) Grasping at sticks: Dissociations between perception and action. Experimental Brain Research, 157, 397-402

Hughes LE, Wilkins AJ (2002). Reading at a distance: implications for the design of text in children's big books. British Journal of Educational Psychology, 72,2,213-226

Hughes L, Wilkins A (2000) Typography in children's reading schemes may be suboptimal: evidence from measures of reading rate. Journal of Research in Reading, 23, 3, 314-324.

BOOK CHAPTERS

Dain SJ and Hughes LE (2003) Survey of the colour vision demands in fire-fighting. In J.D. Mollon, J. Pokorny & K. Knoblauch Normal and Defective Colour Vision. Oxford: Oxford University Press.