Over the course of our lifetimes, each of us has unique experiences: we may receive a certain education, develop unique abilities, and suffer particular diseases or setbacks. How does the brain change in dialogue with experience over the lifespan, and which factors contribute to its health and flourishing? In order to answer this question, the Lifebrain project has brought together data from 18,500 research participants collected in 11 European brain-imaging studies – including our very own CamCAN and CALM studies. Through the collaborative efforts of outstanding researchers, findings from the Lifebrain project are beginning to sketch a complete picture of brain development, mental health, and cognition across the entirety of a human lifetime.