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Neural activations and representations during episodic versus semantic memory retrieval
Authors:
Tibon, R., GREVE, A., HUNPHREYS, G., Quent, J.A., HENSON, R.
Reference:
Nature Human Behaviour, 27 Jan 2026
Year of publication:
2026
CBU number:
9251
Abstract:
While the distinction between episodic and semantic memory is supported by numerous neuropsychological studies, neuroimaging data have shown considerable overlap between regions that are activated during semantic and episodic remembering. This might indicate similar or shared mechanisms but might also result from inadequate task designs or poor fMRI signal coverage. In this Registered Report, we compared neural activations and representations associated with successful retrieval of episodic and semantic memories, using tasks that are more closely matched. n=40 participants recalled pairings between logos and brand names, where the pairings corresponded to real-world knowledge (semantic task), or were learned in an initial study phase (episodic task). Neither a-priori defined networks, nor clusters generally activated by our task, provided evidence for any difference between successful semantic and episodic retrieval, with the Bayes Factor for the a priori networks supporting the null hypothesis of no difference.
MRC Cognition and Brain Sciences Unit

