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Cognitive Dysfunction in Non-Demented Parkinson's Disease
Authors:
Cools, R., Swainson, R., OWEN, A.M. & Robbins, T.W.
Reference:
In Wolters, E.C.H., Cheltens, P.H., Berendse, H.W. (Eds), Mental Dysfunction In Parkinson's disease, pp.142-164. Academic Pharmaceutical Productions, Utrecht, The Netherlands, 2000.
Year of publication:
2000
CBU number:
4009
Abstract:
We surveyed deficits in attentional set-shifting, working memory and planning in patients at different stages of Parkinson’s disease (PD). these functions are all sensitive to frontal lobe damage and exhibit considerable selectivity. Thus, the attentional set-shifting deficit is paralleled by impairments in task set-shifting, uncontaminated by learning. The working memory deficits are found more readily in the spatial domain. Recent evidence of both positive and deleterious effects of dopaminergic medication is reviewed. Finally, the neural substrates of cognitive deficits in PD and their response to medication is surveyed in a functional neuroimaging context.
