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Left egocentric neglect in early subacute right-stroke patients is related to damage of the superior longitudinal fasciculus
Authors:
Spanò, B., NARDO, D., Giulietti, G., Matano, A., Salsano, I., Briani, C., Vadalà, R., Marzi, C., De Luca, M., Caltagirone, C., Santangelo, V.
Reference:
Brain Imaging and Behavior, 30 Jul 2021, 16(1):211-218
Year of publication:
2021
CBU number:
8716
Abstract:
A typical consequence of stroke in the right hemisphere is unilateral spatial
neglect. Distinct forms of neglect have been described, such as space-based (egocentric)
and object-based (allocentric) neglect. However, the relationship between these two
forms of neglect is still far from being understood, as well as their neural substrates.
Here, we further explore this issue by using voxel lesion symptoms mapping (VLSM)
analyses on a large sample of early subacute right-stroke patients assessed with the
Apples Cancellation Test. This is a sensitive test that simultaneously measures both
egocentric and allocentric neglect. Behaviourally, we found no correlation between
egocentric and allocentric performance, indicating independent mechanisms supporting
the two forms of neglect. This was confirmed by the VLSM analysis that pointed out a
link between a damage in the superior longitudinal fasciculus and left egocentric neglect.
By contrast, no association was found between brain damage and left allocentric neglect.
These results indicate a higher probability to observe egocentric neglect as a consequence
of white matter damages in the superior longitudinal fasciculus, while allocentric neglect
appears more “globally” related to the whole lesion map. Overall, these findings on early
subacute right-stroke patients highlight the role played by white matter integrity in
sustaining attention-related operations within an egocentric frame of reference.
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