skip to primary navigation skip to content

CBSU bibliography search

To request a reprint of a CBSU publication, please click here to send us an email (reprints may not be available for all publications)

Concurrent neuroimaging and neurostimulation reveals a causal role for dlPFC in coding of task-relevant information
JACKSON, J., Feredoes, E., Rich, A.N., Lindner, M. WOOLGAR, A.
Communications Biology, 4(1), 588
Year of publication:
CBU number:
Dorsolateral prefrontal cortex (dlPFC) is proposed to drive brain-wide focus by biasing processing in favour of task-relevant information. A longstanding debate concerns whether this is achieved through enhancing processing of relevant information and/or by inhibiting irrelevant information. To address this, we applied transcranial magnetic stimulation (TMS) during fMRI, and tested for causal changes in information coding. Participants attended to one feature, whilst ignoring another feature, of a visual object. If dlPFC is necessary for facilitation, disruptive TMS should decrease coding of attended features. Conversely, if dlPFC is crucial for inhibition, TMS should increase coding of ignored features. Here we show that TMS decreases coding of relevant information across frontoparietal cortex, and the impact is significantly stronger than any effect on irrelevant information, which is not statistically detectable. This provides causal evidence for a specific role of dlPFC in enhancing task-relevant representations and demonstrates the cognitive-neural insights possible with concurrent TMS-fMRI-MVPA .
Data for this project is available at: