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An MEG correlate of word recognition
PULVERMULLER, F., SHTYROV, Y., Ilmoniemi, R. & MARSLEN-WILSON, W.D.
In: Fourth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, p.115
Year of publication:
A fundamental challenge for the cognitive neuroscience of language is to capture the spatio-temporal patterns of brain activity that underlie critical functional components of the language comprehension process. We combine here psycholinguistic analysis, whole-head magnetoencephalography (MEG), the Mismatch Negativity (MMN) paradigm, and state-of-the-art source localisation techniques (Equivalent Current Dipole and L1-Minimum-Norm Current Estimates) to locate the process of spoken word recognition at a precise moment in space and time. The magnetic MMN to words presented as rare "deviant stimuli" in an oddball paradigm among repetitive "standard" speech stimuli, peaked 100-150ms after the information in the acoustic input was sufficient for word recognition. The latency with which words were recognised corresponded to that of an MMN source in the left superior temporal cortex. There was a significant correlation (r=0.7) of latency measures of word recognition in individual study participants with the latency of the activity peak of the superior temporal source. These results demonstrate a correspondence between the behaviorally determined recognition point for spoken words and the cortical activation in left superior temporal areas. Both the MMN calculated in the classic manner, obtained by subtracting standard from deviant stimulus response recorded in the same experiment, and the identity MMN(iMMN), defined as the difference between the neuromagnetic responses to the same stimulus presented as standard and deviant stimulus, showed the same correlation with word recognition processes.