Systems Neuroscience of Human Memory and its Disorders
The aim of this work is to understand how our brains enable our memories. Specifically, we use the techniques of fMRI and EEG/MEG to examine brain activity as healthy volunteers try to remember things in the laboratory, and relate these findings to the memory problems following brain damage. We are interested in the neural bases of both explicit (conscious) memory and implicit (unconscious) memory, particularly the relationship between recollection, familiarity, and priming, and the relationship between memory and perception. A deeper knowledge of these different expressions of memory is important for understanding the memory impairments associated with neurological damage, with normal “healthy” ageing and with neurodegenerative diseases such as dementia.
This framework guides our computational, behavioural, fMRI and M/EEG experiments, aimed at testing the dynamics of PE reduction in the brain, and how PE drives synaptic change and new learning. We are also interested in how prior knowledge (schema) can help new learning, such as the SLIMM model we developed in van Kesteren et al (2012).
Henson, R.N. & Gagnepain, P. (2010). Predictive, Interactive Multiple Memory Systems. Hippocampus, 20, 1315-1326.
Van Kesteren, M.T.R., Ruiter, D.J., Fernández, G. & Henson, R.N. (2012). How schema and novelty augment memory formation. Trends in Neurosciences, 35, 211-219.
Greve, A., Cooper, E., Kaula, A., Anderson, M.C. & Henson, R.N. (2017). Does Prediction Error drive one-shot declarative learning? Journal of Memory and Language, 94, 149-165.
Barense, M.D, Groen, I, Lee, A.C, Yeung, L-K, Brady, S.M, Gregori, M, Kapur, N, Bussey, T.J, Saksida, L.M. & Henson, R.N. (2012). Intact memory for ir-relevant information impairs perception in amnesia. Neuron, 75, 157-167.
Staresina, B.P., Fell, J. Do Lam, A.T.A., Axmacher, N. & Henson, R.N. (2012). Memory signals are temporally dissociated within and across human Hippocampus and Perirhinal cortex. Nature Neuroscience, 15, 1167-1173.
Henson, R.N., Greve, A., Cooper, E., Gregori, M., Simons, J.S., Geerligs, L., Erzinçlioğlu, S., Kapur, N. & Browne, G. (2016). The effects of hippocampal lesions on MRI measures of structural and functional connectivity. Hippocampus, 26, 1447–1463.
Greve, A., Cooper, E. & Henson, R.N. (2014). No evidence that ‘fast-mapping’ benefits novel learning in healthy older adults. Neuropsychologia, 60, 52-59.
Henson, R.N., Campbell, K.L., Davis, S.W., Taylor, J.R., Emery, T., Erzinclioglu, S., Cam-CAN & Kievit, R.A. (2016). Multiple determinants of lifespan memory differences. Scientific Reports, 6:32527.
Cooper, E., Greve, A. & Henson, R.N. (2017). Assumptions behind Scoring Source versus Item Memory: Effects of Age, Hippocampal Lesions and Mild Memory Problems. Cortex, 91, 297-315.
Maestu, F., Peña, J.M., Garcés, P., Gonzalez, S., Bajo, R., Bagic, A., Cuesta, P., Funke, M., Makela, J. Menasalvas, E., Nakamura, A., Parkkonen, L., Lopez, M.E., del Pozo, F., Sudre, G., Zamrini, E., Pekkonen, E., Henson, R. & Becker, J. (2015). A multicenter study of the early detection of synaptic dysfunction in mild cognitive impairment using magnetoencephalography-derived functional connectivity. Neuroimage: Clinical, 9, 103-109.
Dr Andrea Greve (MRC Band 4 Postdoc)
Dr Elisa Cooper (MRC Band 4 Postdoc)
Dr Roni Tibon (Newton Fellow)
Dr Aya Ben-Yakov (EU Marie Curie Fellow)
Dr Renee Visser (EU Marie Curie Fellow)
Dr Darren Price (MRC CamCAN Postdoc)
Mr Alex Kaula (MRC PhD Student)
Ms Rebecca Beresford (MRC UK MEG PhD student)
Mr Jiri Cevora (MRC PhD Student)
Dr Hunar Ahmad (Cambridge International PhD Scholarship)
Dr David Nesbitt (MD/PhD)