Clinical syndromes caused by frontotemporal lobar degeneration (FTLD), including the behavioral variant frontotemporal dementia (bvFTD) and progressive supranuclear palsy (PSP), are pathologically distinct but share many behavioural, cognitive and physiological features. These shared features may in part occur from common deficits of major neurotransmitters like GABA. To further investigate the link between GABA deficits and […]
Behavioural disinhibition, glutamate, and GABA: mechanisms of frontotemporal lobar degeneration
Behavioural disinhibition is a common feature of frontotemporal lobar degeneration (FTLD) syndromes. Impulsive behaviour in several neuropsychiatric diseases and FTLD have been linked with reduced levels of the neurotransmitters, glutamate and GABA. This study aimed to investigate, through a transdiagnostic approach, whether prefrontal glutamate and GABA levels are reduced by FTLD and if these deficits […]
A transdiagnostic approach to capture the clinical spectrum of frontotemporal lobar degeneration
Frontotemporal lobar degeneration (FTLD) syndromes are highly heterogeneous and overlapping in their clinical phenotype and brain morphometry. Thus, utilizing a transdiagnostic approach to capture the heterogeneous nature of FTLD is important for understanding and treating FTLD syndromes. The primary hypothesis of this study was that syndromes associated with FTLD are multidimensional rather than discrete clinical […]
The early role of apathy in frontotemporal dementia
A common feature of frontotemporal dementia (FTD) is apathy. Having apathy symptoms, including deficits in working memory and mental/cognitive flexibility, has been linked to worse prognosis and survival for FTD patients. However, its role as an early marker of FTD progression is unclear. The aim of this study was to assess whether apathy in presymptomatic […]
Frontotemporal lobar degeneration: a spectrum of cognitive decline
Degeneration in the frontal lobes of the brain can produce many different syndromes, which have highly variable and overlapping clinical features. While clinical diagnostic criteria for these conditions has been refined in the last decade, a transdiagnostic approach to frontal lobe degeneration—which looks at variations in cognitive and behavioural traits, rather than diagnostic labels—may prove […]
Is apathy a key driver of frontotemporal dementia?
Frontotemporal dementia (FTD) is a neurodegenerative disorder that affects regions of the brain involved in key cognitive functions, such as abstract reasoning and emotion regulation. Apathy—a multifaceted construct that describes a range of behavioural and cognitive impairments—has been associated with worse outcomes in FTD. In this study, researchers aimed to understand whether apathy begins to […]
Keeping the beat: how the brain processes the rhythms of speech
When the brain encounters a rhythm—for instance, through music, or direct electrical stimulation—it aligns its oscillation patterns (‘brainwaves’) to the beat. However, it is unclear if these stimulus-aligned brain responses are internally driven—through the brain’s own underlying patterns of activity—or if they are evoked by the rhythm of the stimulus itself. In this study, researchers […]
Mind over Matter: how hippocampal GABA enables inhibitory control over unwanted thoughts
We can’t always control what we think, for those with psychiatric disorders, this is especially challenging. Intrusive memories, flashbacks, and hallucinations are hallmark symptoms of a variety of mental health conditions. Although these symptoms are often attributed to problems with brain regions that help us inhibit unwanted thoughts—such as the prefrontal cortex—difficulties in controlling intrusive […]
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