skip to primary navigation skip to content

CBSU bibliography search

To request a reprint of a CBSU publication, please click here to send us an email (reprints may not be available for all publications)

Evidence for a pervasive autobiographical memory impairment in Logopenic Progressive Aphasia
RAMANAN, S., Foxe, D., El-Omar, H., Ahmed, R.M., Hodges, J.R., Piguet, O., Irish, M.
Neurobiology of Aging, 108, 168-178
Year of publication:
CBU number:
Although characterized primarily as a language disorder, mounting evidence indicates episodic amnesia in Logopenic Progressive Aphasia (LPA). Whether such memory disturbances extend to information encoded pre-disease onset remains unclear. To address this question, we examined autobiographical memory in 10 LPA patients, contrasted with 18 typical amnestic Alzheimer’s disease and 16 healthy Control participants. A validated assessment, the Autobiographical Interview, was employed to explore autobiographical memory performance across the lifespan under free and probed recall conditions. Relative to Controls, LPA patients showed global impairments across all time periods for free recall, scoring at the same level as disease-matched cases of Alzheimer’s Disease. Importantly, these retrieval deficits persisted in LPA, even when structured probing was provided, and could not be explained by overall level of language disruption or amount of information generated during autobiographical narration. Autobiographical memory impairments in LPA related to grey matter intensity decrease in predominantly posterior parietal brain regions implicated in memory retrieval. Together, our results suggest that episodic memory disturbances may be an under-appreciated clinical feature of LPA.
Data for this project is held by an external institution. Please contact the authors to request a copy.