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Efficient experimental design for fMRI.
In Statistical Parametric Mapping: The analysis of functional brain images, K. Friston, J. Ashburner, S. Kiebel, T. Nichols, and W. Penny (Eds). Elsevier, London, 2006.
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This chapter begins with an overview of the various types of experimental design, before proceeding to various modelling choices, such as the use of events versus epochs. It then covers some practical issues concerning the effective temporal sampling of BOLD responses and the problem of different slice acquisition times. The final and main part of the chapter concerns the statistical efficiency of fMRI designs, as a function of Stimulus Onset Asynchrony (SOA) and the ordering of different stimulus-types. These considerations allow researchers to optimise the efficiency of their fMRI designs.