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CBU bibliography
This is a searchable list of all CBU publications. It includes abstracts and all other details. Offprints are sometimes available.
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Page: 1 # Medial temporal lobe activity during complex discrimination of faces, objects and scenes: effects of viewpoint
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| CBU number: | 6981 |
| Authors: | Barense, M, HENSON, R.N. Lee, A. & Graham, K.J. |
| Reference: | Hippocampus |
| Year of publication: | In Press |
| Annual report number: | CBUAR 54 |
# Age-related changes in neural activity associated with familiarity, recollection and false recognition
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| CBU number: | 6845 |
| Authors: | Duarte, A., Graham, K. & HENSON, R. |
| Reference: | Neurobiology of Aging |
| Year of publication: | In Press |
| Annual report number: | CBUAR 53 |
# Memory and perceptual impairments in amnesia and dementia.
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| CBU number: | 6603 |
| Authors: | Graham, K.S., Lee, A.C.H. & BARENSE, M.D. |
| Reference: | In: Handbook of Behavioural Neuroscience: Episodic Memory Research (Dere E, Easton A, Huston J, eds): Elsevier BV. |
| Year of publication: | In Press |
| Annual report number: | CBUAR 52 |
| Keywords: | Book Chapter |
# Impairments in visual discrimination in amnesia: Implications for theories of the role of medial temporal lobe regions in human memory.
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| CBU number: | 6604 |
| Authors: | Graham, K.S., Lee, A.C.H., BARENSE, M.D. |
| Reference: | European Journal of Cognitive Psychology |
| Year of publication: | In Press |
| Annual report number: | CBUAR 52 |
# Re-acquisition of person knowledge in semantic memory disorders
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| CBU number: | 6866 |
| Authors: | Dewar, B-K. WILSON, B., PATTERSON, K. & Graham, K. |
| Reference: | Neuropsychological Rehabilitation, 19(3), 383-341 |
| Year of publication: | 2009 |
| Annual report number: | CBUAR 53 |
# Temporal lobe activity during complex discriminations of familiar and novel objects and faces
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| CBU number: | 6767 |
| Authors: | BARENSE, M.D., HENSON, R.N.A. & Graham, K.S. |
| Reference: | Fifteenth Cognitive Neuroscience Society Annual Meeting, F93 |
| Year of publication: | 2008 |
| Abstract text: | Recent studies indicate that structures in the medial temporal lobe (MTL) support processes beyond long-term declarative memory, including complex visual discrimination. For example, amnesic patients with circumscribed hippocampal lesions had selective difficulties making oddity judgements for scenes shown simultaneously from multiple viewpoints, but not those presented from the same viewpoint. Patients with larger MTL lesions, including damage to the perirhinal cortex, showed additional problems with oddity judgement for faces presented from different, but not the same, viewpoints (Lee et al, ... [more] |
| First CBU author: | BARENSE, M.D. |
| Annual report number: | CBUAR 53 |
| Keywords: | Conference Proceedings and Published Abstracts, Poster |
# Temporal lobe activity during complex discriminations of meaningful and novel objects and faces.
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| CBU number: | 6769 |
| Authors: | BARENSE, M.D., HENSON, R.N.A. & Graham, K.S. |
| Reference: | Experimental Psychology Society Meeting - April 2008 |
| Year of publication: | 2008 |
| Abstract text: | Recent studies indicate that structures in the medial temporal lobe (MTL) support processes beyond long-term declarative memory, including perception. In addition, there appears to be an influence of stimulus meaningfulness on discrimination ability in patients with temporal lobe damage. For example, discrimination performance in patients with focal MTL lesions (e.g., from herpes viral encephalitis) was improved by the use of meaningful stimuli. By contrast, patients with semantic dementia, a neurodegenerative condition characterised by progressive deterioration of conceptual knowledge and atrophy ... [more] |
| First CBU author: | BARENSE, M.D. |
| Annual report number: | CBUAR 53 |
| Keywords: | Conference Proceedings and Published Abstracts, Paper |
# The effects of aging on the neural correlates of subjective and objective recollection
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| CBU number: | 6616 |
| Authors: | Duarte, A., HENSON, R. & Graham, K. |
| Reference: | Cerebral Cortex, 18(9), 2169-2180 |
| Link: | Link |
| Year of publication: | 2008 |
| Annual report number: | CBUAR 52 |
# Activating the Medial Temporal Lobe during Oddity Judgement for Faces and Scenes
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| CBU number: | 6744 |
| Authors: | LEE, A.C.H., Scahill, V. & GRAHAM, K.S. |
| Reference: | Cerebral Cortex 18(3) 683-696 |
| Link: | Link |
| Year of publication: | 2008 |
| Abstract text: | Impairments in visual discrimination beyond long-term declarative memory have been found in amnesic individuals, with hippocampal lesions resulting in deficits in scene discrimination and perirhinal cortex damage affecting object discrimination. To complement these findings, the present functional magnetic resonance imaging study found that in healthy participants oddity judgment for novel trial-unique scenes, compared with face or size oddity, was associated with increased posterior hippocampus and parahippocampal cortex activity. In contrast, perirhinal and anterior hippocampus activity was observed ... [more] |
| First CBU author: | LEE. A.C.H. |
| Annual report number: | CBUAR 52 |
# Evidence for stimulus-specific but not process-specific contributions of MTL structures to recognition memory for faces and scenes.
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| CBU number: | 6820 |
| Authors: | Taylor, K., Graham, K., SCHWARZBAUER, C. & HENSON, R. |
| Reference: | Proceedings of the 38th Annual Meeting of the Society for Neuroscience |
| Year of publication: | 2008 |
| Abstract text: | We have previously demonstrated that whereas amnesic patients with broad medial temporal lobe (MTL) damage show impaired recognition memory (RM) for faces and spatial scenes, patients with circumscribed hippocampal lesions show a selective preservation of face RM. We proposed that the selective RM deficit associated with hippocampal damage was the result of specialisation within the MTL according to stimulus category, with the hippocampus and perirhinal cortex playing essential roles in scene and object processing respectively. An alternative explanation, however, which follows from dual-process ... [more] |
| Annual report number: | CBUAR 53 |
| Keywords: | Conference Proccedings and Published Abstracts |
# Influence of conceptual knowledge on visual object discrimination
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| CBU number: | 6519 |
| Authors: | BARENSE, M. & GRAHAM, K. |
| Reference: | Fourteenth Annual Meeting of the Cognitive Neuroscience Society, F114 |
| Year of publication: | 2007 |
| Abstract text: | Although recent studies have highlighted the key role played by the perirhinal cortex in complex object processing, it is not currently clear whether this region also contributes to semantic processing of objects. To address this issue, object processing for meaningful (e.g., familiar real world objects) and novel (e.g., barcodes, blobs, greebles) stimuli was investigated in individuals presenting with a significant loss of conceptual knowledge in the context of semantic dementia (SD), a progressive condition that affects anterior and medial temporal lobe (MTL) regions (including perirhinal cortex). ... [more] |
| Annual report number: | CBUAR 52 |
| Keywords: | Conference Proceedings and Published Abstracts |
# Medial temporal lobe activation during oddity judgements for objects, faces and scenes
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| CBU number: | 6509 |
| Authors: | BARENSE, M., Lee, A., HENSON, R. & GRAHAM, K. |
| Reference: | 13th Annual Meeting of the Organization for Human Brain Mapping, S118 |
| Year of publication: | 2007 |
| Abstract text: | Recent studies indicate that structures in the medial temporal lobe (MTL) support processes beyond long-term declarative memory, including complex visual discrimination. For example, amnesic patients with circumscribed hippocampal lesions had selective difficulties making oddity judgements for scenes shown simultaneously from multiple viewpoints, but not those presented from the same viewpoint. Patients with larger MTL lesions, including damage to the perirhinal cortex, showed additional problems with oddity judgement for faces presented from different, but not the same, viewpoints (Lee et al, ... [more] |
| Annual report number: | CBUAR 52 |
| Keywords: | Conference Proceedings and Published Abstracts |
# The human medial temporal lobe processes online representations of complex objects
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| CBU number: | 6579 |
| Authors: | BARENSE, M.D., Gaffan, D. & GRAHAM, K.S. |
| Reference: | Neuropsychologia, 45(13), 2963-2974 |
| Year of publication: | 2007 |
| Abstract text: | There has been considerable debate as to whether structures in the medial temporal lobe (MTL) support both memory and perception, in particular whether the perirhinal cortex may be involved in the perceptual discrimination of complex objects with a large number of overlapping features. Similar experiments testing the discrimination of blended images have obtained contradictory findings, and it remains possible that reported deficits in object perception are due to subtle learning in controls, but not patients. To address this issue, a series of trial-unique object "oddity" tasks, in which ... [more] |
| First CBU author: | BARENSE, M.D. |
| Annual report number: | CBUAR 52 |
# The syndrome of transient epileptic amnesia
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| CBU number: | 6429 |
| Authors: | Butler, C.R., GRAHAM, K.S., HODGES, J.R., Kapur, N., Warlaw, J.M. & Zeman, A.Z.J. |
| Reference: | Annals of Neurology, 61(6), 587-598 |
| Year of publication: | 2007 |
| Annual report number: | CBUAR 51 |
# Differing profiles of face and scene discrimination deficits in semantic dementia and Alzheimer's disease
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| CBU number: | 6351 |
| Authors: | Lee, A.C.H., Levi, N., Davies, R.R., HODGES, J.R. & GRAHAM, K.S. |
| Reference: | Neuropsychologia, 45(9), 2135-2146 |
| Year of publication: | 2007 |
| Abstract text: | Recent work in Alzheimer's Disease (AD) and semantic dementia (SD) has reported a double dissociation in AD and SD on tests of visual discrimination, with poor performance on spatial tests in AD and impaired face discrimination in SD. This pattern has been attributed to the different patterns of atrophy seen in the medial temporal lobe (MTL) in these two neurodegenerative conditions. To investigate whether this functional distinction would extend to another task that employed different types of spatial and object stimuli, two groups of AD and SD patients were assessed on a simple test involving ... [more] |
| Annual report number: | CBUAR 51 |
# Colour knowledge in semantic dementia: It is not all black and white
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| CBU number: | 6542 |
| Authors: | Rogers, T.T., PATTERSON, K. & GRAHAM, K.S. |
| Reference: | Neuropsychologia, 45(14), 3285-3298 |
| Year of publication: | 2007 |
| Annual report number: | CBUAR 52 |
# Medial temporal lobe activations in recognition memory: Is stimulus category or recollection versus familiarity the crucial factor?
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| CBU number: | 6762 |
| Authors: | TAYLOR, K.J., GRAHAM, K.S., SCHWARZBAUER & HENSON, R.N.A. |
| Reference: | Fourteenth Annual Meeting of the Cognitive Neuroscience Society, A77 |
| Year of publication: | 2007 |
| Abstract text: | We have recently demonstrated that whilst amnesic patients with broad medial temporal lobe (MTL) damage are impaired in recognition memory (RM) for faces and spatial scenes, patients with damage limited to the hippocampus show a selective preservation of RM for faces. We proposed that it is the nature of scene versus face stimuli that produced the selective RM deficit associated with hippocampal damage. An alternative explanation, however, is that RM for scenes relies more heavily on hippocampally-dependent recollective processes, whereas RM for faces can be mediated by familiarity signals in adjacent ... [more] |
| First CBU author: | TAYLOR, K.J. |
| Annual report number: | CBUAR 53 |
| Keywords: | Conference Proceedings and Published Abstracts |
# Recognition memory for faces and scenes in amnesia: Dissociable roles of medial temporal lobe structures
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| CBU number: | 6499 |
| Authors: | TAYLOR, K.J., HENSON, R.N.A. & GRAHAM, K.S. |
| Reference: | Neuropsychologia, 45(11), 2428-2438. |
| Year of publication: | 2007 |
| Abstract text: | The relative contributions of the hippocampus and the perirhinal cortex to recognition memory are currently the subject of intense debate. Whereas some authors propose that both structures play a similar role in recognition memory, others suggest that the hippocampus might mediate recollective and/or associative aspects of recognition memory, whereas the perirhinal cortex may mediate item memory. Here we investigate an alternative functional demarcation between these structures, following reports of stimulus-specific perceptual deficits in amnesics with medial temporal lobe (MTL) lesions. Using ... [more] |
| First CBU author: | TAYLOR, K.J. |
| Annual report number: | CBUAR 52 |
# Medial temporal lobe activation during oddity judgements for objects, faces, and scenes
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| CBU number: | 6522 |
| Authors: | BARENSE, M. D. ., LEE, A.C. & GRAHAM, K.S. |
| Reference: | Program No. 777.12 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience, 2006. Online. |
| Year of publication: | 2006 |
| Abstract text: | Recent studies indicate that structures in the medial temporal lobe (MTL) support processes beyond long-term declarative memory, including complex visual discrimination. For example, amnesic patients with circumscribed hippocampal lesions have selective difficulties making oddity judgements for scenes shown simultaneously from multiple viewpoints, but not those presented from the same viewpoint. Patients with larger MTL lesions, including damage to the perirhinal cortex, show additional problems with oddity judgement for faces presented from different, but not the same, viewpoints (Lee et al, 2005). ... [more] |
| First CBU author: | BARENSE, M.D. |
| Annual report number: | CBUAR 52 |
| Keywords: | Conference Proceedings and Published Abstracts |
# Impaired object perception in amnesic individuals with medial temporal lobe lesions.
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| CBU number: | 6521 |
| Authors: | BARENSE, M.D., Gaffan, D. & GRAHAM, K.S. |
| Reference: | Thirteenth Annual Meeting of the Cognitive Neuroscience Society, A8 |
| Year of publication: | 2006 |
| Abstract text: | There has been considerable debate as to whether structures in the medial temporal lobe (MTL) support both memory and perception. Specifically, the perirhinal cortex may be involved in the perceptual discrimination of complex objects with a large number of overlapping features. To test this view, we administered a series of “oddity” tasks, in which subjects selected the odd stimulus from a visual array, to amnesic patients with either selective bilateral damage to the hippocampus or more extensive damage to MTL regions, including the perirhinal cortex. Whereas patients with damage limited ... [more] |
| First CBU author: | BARENSE, M.D. |
| Annual report number: | CBUAR 52 |
| Keywords: | Conference Proceedings and Published Abstracts |
# New Insights about the genesis of memory deficits in amnesia
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| CBU number: | 6520 |
| Authors: | BARENSE, M.D., Lee, A.C.H. & GRAHAM, K.S |
| Reference: | Poster presented at the MRC Showcase Event: Breakthroughs in neuroscience and mental health. London, Uk, December 7-8, 2006 |
| Year of publication: | 2006 |
| Abstract text: | The status of medial temporal lobe (MTL) regions in memory is controversial. While studies in humans suggest this region functions as a unitary memory system, animal investigations have revealed functional specialisation, with the perirhinal cortex and hippocampus playing unique roles in object and spatial memory, respectively. Even more contentiously, some animal experiments have highlighted a broader role for these structures in the perception of object and spatial stimuli. To address this issue, oddity tasks sensitive to MTL lesions in the nonhuman primate literature were adapted for use in ... [more] |
| First CBU author: | BARENSE, M.D. |
| Annual report number: | CBUAR 52 |
| Keywords: | Conference Proceedings and Published Abstracts |
# One bird with two stones: Abnormal word length effects in pure alexia and semantic dementia
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| CBU number: | 6242 |
| Authors: | CUMMING, T., PATTERSON, K., Verfaellie, M. & GRAHAM, K.S. |
| Reference: | Cognitive Neuropsychology, 23(8), 1130-1161. |
| Year of publication: | 2006 |
| Abstract text: | In pure alexia (PA) - an acquired reading disorder consequent on posterior left-hemisphere stroke ñ the hallmark is a pronounced and abnormal impact of word length on reading speed. Some patients with semantic dementia (SD) - a neurodegenerative condition affecting semantic memory ñ have also been reported to show an abnormal word length effect (AWLE) in reading, even though they are not thought to have the basic visual-processing deficits hypothesised to underlie this phenomenon in PA. In the current study, an AWLE in reading was consistently observed in both PA and SD patients, but further ... [more] |
| First CBU author: | Graham, K.S. |
| Annual report number: | CBUAR 51 |
# Repetition priming and hyperpriming in semantic dementia
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| CBU number: | 6290 |
| Authors: | CUMMING, T.B., GRAHAM, K.S. & PATTERSON, K. |
| Reference: | Brain and Language, 98(2), 221-234 |
| Year of publication: | 2006 |
| Abstract text: | Evidence from neurologically normal subjects suggests that repetition priming (RP) is independent of semantic processing. Therefore, we may expect patients with a selective deficit to conceptual knowledge to exhibit RP for words regardless of the integrity of their semantic representations. We tested six patients with semantic dementia (SD) on a lexical decision task that incorporated four different lags between first (baseline) and second (primed) presentation of repeated words. The patients exhibited significant RP that was greater for words that were categorised as semantically 'degraded' than ... [more] |
| First CBU author: | Patterson, K. |
| Annual report number: | CBUAR 51 |
| Keywords: | Semantic knowledge, Lexical decision, Cognitive slowing, Implicit memory |
# Can People with Semantic Memory Deficits Re-learn Information?
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| CBU number: | 6385 |
| Authors: | DEWAR, B-K., WILSON, B.A., PATTERSON, K. & GRAHAM, K.S. |
| Reference: | Journal of the International Neuropsychological Society 12(S2): 21 |
| Year of publication: | 2006 |
| Abstract text: | There have only been a few systematic studies into the acquisition of semantic material in people with semantic memory problems. As part of a larger project to investigate reacquisition of semantic material in cases of impaired semantic memory due to both progressive (semantic dementia) and non progressive (encephalitis) aetiologies, here we report the training of two patients post encephalitis. Selecting the semantic category of famous people, we trained each subject on ten items each consisting of a photograph (e.g. of Tony Blair), the corresponding name and a semantic fact (e.g. Longest serving ... [more] |
| First CBU author: | DEWAR, B-K. |
| Annual report number: | CBUAR 51 |
| Keywords: | Conference Proceedings and Published Abstracts |
# Abnormal Categorization and Perceptual Learning in Patients with Hippocampal Damage
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| CBU number: | 6266 |
| Authors: | GRAHAM, K., SCAHILL, V., HORNBERGER, M., BARENSE, M., LEE, A., Bussey, T. & Saksida, L |
| Reference: | The Journal of Neuroscience, 26(29), 7547–7554 |
| Year of publication: | 2006 |
| Abstract text: | Prevailing theory holds that the medial temporal lobe (MTL) subserves declarative memory exclusively, whereas nondeclarative memory is independent of this brain region. Recent studies in patients with amnesia, however, have shown that performance on declarative memory tasks may not always be dependent on a single MTL memory system, instead highlighting the critical role of anatomically distinct structures in processing different stimulus types. In particular, the hippocampus has been implicated in spatial memory, whereas perirhinal cortex seems critical for object memory. To assess whether stimulus ... [more] |
| First CBU author: | GRAHAM, K.S. |
| Annual report number: | CBUAR 51 |
# "A horse of a different colour". Do patients with semantic dementia recognise different versions of the same object as the same?
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| CBU number: | 6105 |
| Authors: | Ikeda, M., PATTERSON, K., GRAHAM, K.S., Lambon Ralph, M.A. & HODGES, J.R. |
| Reference: | Neuropsychologia, 44(4), 566-575 |
| Year of publication: | 2006 |
| Abstract text: | Ten patients with semantic dementia resulting from bilateral anterior temporal-lobe atrophy, and ten matched controls, were tested on an object recognition task in which they were invited to choose (from a 4-item array) the picture representing "the same thing" as an object picture that they had just inspected and attempted to name. The target in the response array was never physically identical to the studied picture but differed from it ; in the various conditions ; in size, angle of view, colour or exemplar (e.g., a different breed of dog). In one test block for each patient, ... [more] |
| First CBU author: | Patterson, K. |
| Annual report number: | CBUAR 50 |
| Keywords: | Temporal-lobe atrophy, Semantic knowledge, Object recognition, Visual perception, Generalisation |
# Perirhinal cortex activity during visual object discrimination
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| CBU number: | 6317 |
| Authors: | LEE, A.C.H., BANDELOW, S., SCHWARZBAUER, C., HENSON, R.N.A. & GRAHAM, K.S. |
| Reference: | NeuroImage, 33(1), 362-373 |
| Year of publication: | 2006 |
| Abstract text: | Previous fMRI studies have demonstrated preferential involvement of the perirhinal cortex and hippocampus in tasks of object and spatial memory, respectively. Here we investigated whether similar activity would also be present when object and spatial discrimination was assessed in the absence of explicit declarative memory demands. On each trial in the scanner, participants were presented simultaneously with two arrays of objects and were asked to indicate whether both arrays were identical, differed with respect to the identity of one object or differed with respect to the spatial arrangement ... [more] |
| First CBU author: | LEE, A.C.H. |
| Annual report number: | CBUAR 51 |
| Keywords: | CBUImaging |
# Differentiating the roles of the hippocampus and perirhinal cortex in processes beyond long-term declarative memory: A double blind dissociation in dementia
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| CBU number: | 6250 |
| Authors: | LEE, A.C.H., Buckley, M.J., Gaffan, D., EMERY, T., HODGES, J.R. & GRAHAM, K.S. |
| Reference: | Journal of Neuroscience, 26(19), 5198-5203 |
| Year of publication: | 2006 |
| Abstract text: | There is increasing evidence to suggest that the hippocampus and perirhinal cortex may mediate processes beyond long-term declarative memory. We assessed patients with Alzheimerís Disease (AD) or semantic dementia (SD) on a visual oddity judgement task that did not place an explicit demand on long-term memory and is known to be sensitive to hippocampal and perirhinal cortex lesions. Importantly, within the medial temporal lobe, AD is associated with predominant hippocampal atrophy, while SD patients have greater perirhinal cortex damage. The AD group was selectively impaired in oddity judgement ... [more] |
| First CBU author: | Lee, A.C.H. |
| Annual report number: | CBUAR 51 |
| Keywords: | memory, perception, amnesia, Alzheimer's disease, semantic dementia, discrimination |
# Elucidating the role of medial temporal lobe regions in recognition memory
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| CBU number: | 6309 |
| Authors: | TAYLOR, K.J, HENSON, R.N.A. & GRAHAM, K.S. |
| Reference: | Thirteenth Annual Meeting of the Cognitive Neuroscience Society, C106 |
| Year of publication: | 2006 |
| Abstract text: | There is disagreement as to whether or not the hippocampus and surrounding cortex, in particular the perirhinal cortex, make distinct contributions to recognition memory in humans. To investigate this issue, we developed a novel forced-choice recognition memory test using pictures of unfamiliar faces and spatial scenes. At test, each studied item was presented either from the same view or a novel view (as compared with that shown during encoding), alongside a visually similar foil. Two patient groups were tested, one with selective bilateral damage to the hippocampus and a second with additional ... [more] |
| First CBU author: | TAYLOR, K.J. |
| Annual report number: | CBUAR 51 |
| Keywords: | Conference Proceedings and Published Abstracts |
# Semantic dementia and primary progressive aphasia: two sides of the same coin?
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| CBU number: | 6064 |
| Authors: | ADLAM, A.L.R., ROGERS, T., GRAHAM, K., PATTERSON, K. & HODGES, J.R. |
| Reference: | Twelfth Annual Meeting of the Cognitive Neuroscience Society, 130 |
| Year of publication: | 2005 |
| Abstract text: | We previously reported that patients with semantic dementia (SD) have deficits in both verbal and non-verbal semantic memory (Bozeat et al., 2000; 2002; Hodges et al., 2000). Some authors suggest that this profile is different to that seen in primary progressive aphasia (PPA) and that the pathology in SD encompasses both left-hemisphere language and bilateral inferotemporal-fusiform networks for faces and objects (e.g., Mesulam et al., 2003). We present data on 7 patients who presented with a clinical profile consistent with PPA. All patients showed bilateral pathology in the anterior temporal ... [more] |
| First CBU author: | Adlam, A.L.R. |
| Annual report number: | CBUAR 50 |
| Keywords: | Conference Proceedings and Published Abstracts |
# Functional specialization in the human medial temporal lobe
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| CBU number: | 6162 |
| Authors: | BARENSE, M.D., Bussey, T.J., LEE, A.C.H., Rogers, T.T., Davies, R.R., Saksida, R.R., Murray, E.A., GRAHAM, K.S. |
| Reference: | Journal of Neuroscience, 24(44), 10239-10246 |
| Year of publication: | 2005 |
| Abstract text: | Investigations of memory in rats and non-human primates have demonstrated functional specialization within the medial temporal lobe (MTL), a set of heavily interconnected structures including the hippocampal formation and underlying entorhinal, perirhinal and parahippocampal cortices. Most studies in humans, however, especially in patients with brain damage, suggest that the human MTL is a unitary memory system supporting all types of declarative memory, our conscious memory for facts and events. To resolve this discrepancy, amnesic patients with either selective hippocampal damage or more extensive ... [more] |
| First CBU author: | BARENSE, M.D |
| Annual report number: | CBUAR 50 |
| Keywords: | Amnesia; Declarative memory; Feature conjunctions; Hippocampus; Medial temporal lobe; Object discrimination; Perception; Perirhinal cortex |
# Feature ambiguity influences performance on novel object discriminations in patients with damage to perirhinal cortex
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| CBU number: | 6091 |
| Authors: | BARENSE, M.D., Bussey, T.J., LEE, A.C.H., ROGERS, T.T., HODGES, J.R., Saksida, L.M., Murray, E.A. & GRAHAM, K.S. |
| Reference: | Twelfth Annual Meeting of the Cognitive Neuroscience Society, 129 |
| Year of publication: | 2005 |
| Abstract text: | Recent studies suggest that the perirhinal cortex may be involved in the perceptual discrimination of complex objects with a large number of overlapping features. To test this view, the performance of a group of semantic dementia (SD) patients, who have asymmetric focal atrophy to the anterolateral temporal lobe, including perirhinal cortex, was assessed on concurrent object discriminations similar to those used in monkeys (Bussey et al, 2002). Subjects learned a series of discriminations between objects with varying levels of perceptual overlap: (a) maximum feature ambiguity, in which all features ... [more] |
| First CBU author: | Barense, M.D |
| Annual report number: | CBUAR 50 |
| Keywords: | Conference Proceedings and Published Abstracts |
# Multidimensional measures of person knowledge and spatial associative learning: can these be applied to the differentiation of Alzheimer's disease from frontotemporal and vascular dementia?
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| CBU number: | 5944 |
| Authors: | CLAGUE, F., Dudas, R.B., Thompson, S.A., GRAHAM, K.S. & HODGES, J.R. |
| Reference: | Neuropsychologia , 43(9), 1338-1350 |
| Year of publication: | 2005 |
| Abstract text: | Patients with early stage Alzheimerís disease (AD) show deficits in person knowledge and spatial associative memory. The current investigation examined the ability of impairment in these domains to differentiate AD from other overlapping conditions. In experiment one, 14 AD patients, 21 vascular dementia (VaD) patients, 11 frontal variant frontotemporal (fvFTD) dementia patients and 41 controls were administered a Graded Faces Test. VaD patients demonstrated a level of impairment comparable to the AD group on both the naming and person identification elements of the task. A mild naming deficit ... [more] |
| First CBU author: | Clague, F. |
| Annual report number: | CBUAR 49 |
| Keywords: | person knowledge, mild cognitive impairment, semantic dementia, diagnosis |
# Episodic and semantic memory in mild cognitive impairment. a total of 75 subjects participated: 22 patients with early AD, 24 with MCI and 29 matched controls.
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| CBU number: | 5963 |
| Authors: | Dudas, R.B., CLAGUE, F., Thompson, S.A., GRAHAM, K.S. & HODGES, J.R. |
| Reference: | Neuropsychologia,43(9), 1266-1276 |
| Year of publication: | 2005 |
| Abstract text: | Little is known about episodic and semantic memory in the early predementia stage of Alzheimer's disease, which is referred to as mild cognitive impairment (MCI). To explore person knowledge, item recognition and spatial associative memory, we designed a Face Place Test (FPT). A total of 75 subjects participated: 22 patients with early AD, 24 with MCI and 29 matched controls. As predicted, AD patients showed significant deficits in person naming, item recognition and recall of spatial location (placing). Surprisingly, subjects with MCI were also impaired on all components. There was no significant ... [more] |
| First CBU author: | Hodges, J.R. |
| Annual report number: | CBUAR 50 |
| Keywords: | Alzheimer disease, MCI, person-specific semantic knowledge, recognition memory, spatial memory |
# Pathologically proven frontotemporal dementia presenting with severe amnesia
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| CBU number: | 5915 |
| Authors: | GRAHAM, A.J., Davies, R., Xuereb, J., Halliday, G.M., Kril, J., Creasey, H., GRAHAM, K.S. & HODGES, J.R. |
| Reference: | Brain, 128, 597-605 |
| Year of publication: | 2005 |
| Abstract text: | Early and severe memory impairment is generally held to be an exclusion criterion for the clinical diagnosis of frontotemporal dementia (FTD). However, clinical experience suggests that some patients with otherwise typical FTD can be amnesic from presentation, or even present solely with amnesia. A review of severe amnesia at presentation in patients with pathologically proven FTD is therefore warranted. The present study reviewed the records of all patients in the joint Cambridge ñ Sydney neuropathological series of patients with dementia and a pathological diagnosis of FTD to identify those ... [more] |
| First CBU author: | Hodges, J.R. |
| Annual report number: | CBUAR 50 |
| Keywords: | Frontotemporal dementia, episodic memory |
# The role of medial temporal lobe regions in memory and perception: evidence from rats, non-human primates and humans
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| CBU number: | 6027 |
| Authors: | GRAHAM, K.S., Gaffan, D |
| Reference: | Quarterly Journal of Experimental Psychology: Section B, 58 (3-4), 193-201 |
| Year of publication: | 2005 |
| Annual report number: | CBUAR 49 |
# Specialization in the medial temporal lobe for processing of objects and scenes
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| CBU number: | 6215 |
| Authors: | LEE, A.C.H., Buckley, M.J., Pegman, S.J., Spiers, H., SCAHILL, V.L., Gaffan, D., Bussey, T., Davies, RR., Kapur, N., HODGES, J.R., GRAHAM, K.S |
| Reference: | Hippocampus, 15, 782-797 |
| Year of publication: | 2005 |
| Abstract text: | There has been considerable debate as to whether the hippocampus and perirhinal cortex may subserve both memory and perception. We administered a series of oddity tasks, in which subjects selected the odd stimulus from a visual array, to amnesic patients with either selective hippocampal damage (HC group) or more extensive medial temporal damage, including the perirhinal cortex (MTL group). All patients performed normally when the stimuli could be discriminated using simple visual features, even if faces or complex virtual reality scenes were presented. Both patient groups were, however, severely ... [more] |
| Annual report number: | CBUAR 50 |
# Specialisation in the medial temporal lobe for processing of objects and scenes
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| CBU number: | 6092 |
| Authors: | LEE, A.C.H., Buckley, M.J., Pegman, S.J., Spiers, H., SCAHILL, V.L., Gaffan, D., Bussey, T.J., Davies, R.R., Kapur, N., Hodges, J.R. & Graham, K.S. |
| Reference: | Hippocampus, 15(6), 782-797 |
| Year of publication: | 2005 |
| Abstract text: | There has been considerable debate as to whether the hippocampus and perirhinal cortex may subserve both memory and perception. We administered a series of non-mnemonic oddity tasks, in which subjects selected the odd stimulus from a visual array, to amnesic patients with either selective hippocampal damage (HC group) or more extensive medial temporal damage, including the perirhinal cortex (MTL group). All patients performed normally when the stimuli could be discriminated using simple visual features, even if faces or complex virtual reality scenes were presented. Both patient groups were, however, ... [more] |
| First CBU author: | Lee, A.C.H. |
| Annual report number: | CBUAR 50 |
# Perceptual deficits in amnesia: challenging the medial temporal lobe 'mnemonic' view
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| CBU number: | 5919 |
| Authors: | LEE, A.C.H., Bussey, T.J., Murray, E.A., Saksida, L.M., Epstein, R.A., Kapur, N., HODGES, J.R. & GRAHAM, K.S. |
| Reference: | Neuropsychologia, 43 (1), 1-11 |
| Year of publication: | 2005 |
| Abstract text: | Recent findings from animal studies have lead to suggestions that the medial temporal lobe (MTL), which is thought to subserve memory exclusively1,2, may support non-mnemonic perceptual processes, with the hippocampus and perirhinal cortex contributing to spatial3,4 and object5-7 perception respectively. There has to date, however, been no complementary support for this view in humans, with lesions to the human MTL resulting in prominent memory deficits8-10 in the context of apparently normal perception11-13. Here we assessed fine visual feature discrimination in amnesic cases to reveal that while ... [more] |
| First CBU author: | LEE, A.C.H. |
| Annual report number: | CBUAR 50 |
| Keywords: | Hippocampus; Perirhinal cortex; Memory; Perception; Visual discrimination |
# The contribution of the human medial temporal lobe to perception: bridging the gap between animal and human studies
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| CBU number: | 6028 |
| Authors: | LEE,A.C.H., BARENSE, M.D., GRAHAM, K.S. |
| Reference: | Quarterly Journal of Experimental Psychology, Section B, 58 (3/4), 300-325 |
| Year of publication: | 2005 |
| Abstract text: | The medial temporal lobe (MTL) has been considered traditionally to subserve declarative memory processes only. Recent studies in nonhuman primates suggests, however, that the MTL may also be critical to higher order perceptual processes, with the hippocampus and perirhinal cortex being involved in scene and object perception, respectively. The current article reviews the human neuropsychological literature to determine whether there is any evidence to suggest that these same views may apply to human MTL. Although the majority of existing studies report intact perception following MTL damage ... [more] |
| Annual report number: | CBUAR 49 |
# Autobiographical Amnesia and Accelerated Forgetting in Transient Epileptic Amnesia
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| CBU number: | 6014 |
| Authors: | Manes, F., GRAHAM, K.S., Zeman, A., Calcagno, M.L. & HODGES, J.R. |
| Reference: | Journal of Neurology, Neurosurgery and Psychiatry, 76(10), 1387-1391 |
| Year of publication: | 2005 |
| Abstract text: | Background: Recurrent brief isolated episodes of amnesia associated with epileptiform discharges on EEG recordings have been interpreted as a distinct entity termed Transient Epileptic Amnesia (TEA). Patients with TEA often complain of autobiographical amnesia for recent and remote events but show normal anterograde memory. Objective: To investigate a) accelerated long-term forgetting and (b) autobiographical memory in a group of TEA patients. Methods: Seven TEA patients and seven age-matched controls were evaluated on a range of anterograde memory tasks on two sessions separated by six weeks ... [more] |
| First CBU author: | Hodges, J.R. |
| Annual report number: | CBUAR 49 |
# Can Episodic Memory Tasks Differentiate Semantic Dementia From Alzheimer’s Disease?
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| CBU number: | 6024 |
| Authors: | SCAHILL, V.L., HODGES, J.R. & GRAHAM, K.S. |
| Reference: | Neurocase, 11(6), 441-451 |
| Year of publication: | 2005 |
| Abstract text: | The performance of two groups of patients with semantic dementia (SD), with predominant right (SDR) and left temporal lobe atrophy (SDL), was contrasted with that of cases with probable Alzheimer's disease (AD) on a range of standard episodic memory tasks. While the SDL group achieved a good score on a composite visual, but not a verbal, episodic memory measure, the AD and SDR groups were equivalently impaired at visual and verbal memory. The SD, but not the AD, groups were, by definition, impaired on simple tests of semantic memory. Standard verbal episodic memory tests, therefore, failed to discriminate ... [more] |
| First CBU author: | Scahill, V.L. |
| Annual report number: | CBUAR 49 |
# Failing to get the gist: Reduced false recognition of semantic associates in semantic dementia
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| CBU number: | 5865 |
| Authors: | Simons, J.S., LEE, A.C.H., GRAHAM, K.S., Verfaellie, M., Koutstaal, W., HODGES, J.R., Schacter, D.L. & Budson, A.E. |
| Reference: | Neuropsychology, 19(3), 353-361 |
| Year of publication: | 2005 |
| Abstract text: | In two experiments involving patients with semantic dementia, the impact of semantic memory loss on both true and false recognition was investigated. The first experiment examined recognition memory for categories of everyday objects that shared a predominantly semantic relationship. There were significant differences between patients and controls in true and false recognition of objects from categories for which a large number of related exemplars were studied, but impairments diminished when category sizes were reduced. Consistent with these results, the patients showed preserved item-specific ... [more] |
| First CBU author: | Hodges, J.R. |
| Annual report number: | CBUAR 50 |
# Differentiating the components of the medial temporal lobe: a critical role for feature ambiguity
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| CBU number: | 6081 |
| Authors: | BARENSE, M.D., Bussey, T.J., LEE, A.C.H., ROGERS, T.T., Saksida, L.M., Murray, E.A., HODGE, J.R. & GRAHAM, K.S. |
| Reference: | Society for Neuroscience, Abstract 201.13 (2004). |
| Year of publication: | 2004 |
| Abstract text: | Studies in nonhuman primates challenge the view that structures in the medial temporal lobe (MTL) constitute a unitary system involved in memory, suggesting instead that MTL regions make independent contributions to both memory and perception. Specifically, the perirhinal cortex may be involved in the perceptual discrimination of complex objects with a large number of overlapping features. To test this view, the performance of two groups of patients, one with selective bilateral hippocampal damage and another with damage to regions in the MTL, including perirhinal cortex, was assessed on concurrent ... [more] |
| First CBU author: | Barense, M.D |
| Annual report number: | CBUAR 50 |
| Keywords: | Conference Proceedings and Published Abstracts |
# The hippocampal region is involved in successful recognition of both remote and recent famous faces
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| CBU number: | 5812 |
| Authors: | Bernard, F.A., Bullmore, E.T., GRAHAM, K.S., Thompson, S.A., HODGES, J.R. & Fletcher, P.C. |
| Reference: | NeuroImage, 22(4), 1704-1714 |
| Year of publication: | 2004 |
| Abstract text: | There is currently a debate regarding the precise role of medial temporal regions in memory, in particular regarding the time scale of their involvement in conscious recollection of information stored in long-term memory. Using event-related fMRI, we have attempted to contribute to this debate by identifying brain regions associated with the successful recognition of famous faces in the 1960s -1970s and "Recent" faces of people who became famous in the 1990s. We demonstrate that the hippocampus is involved in the successful recognition of famous faces from both periods and does not ... [more] |
| First CBU author: | Graham, K.S. |
| Annual report number: | CBUAR 48 |
# The Human Perirhinal Cortex and Semantic Memory
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| CBU number: | 5911 |
| Authors: | Davies, R.R., GRAHAM, K.S., Xuereb, J.H., Williams, G.B. & HODGES, J.H. |
| Reference: | European Journal of Neuroscience, 20(9), 2441-2446 |
| Year of publication: | 2004 |
| Abstract text: | Studies in macaque monkeys indicate that the perirhinal cortex in the temporal lobe participates in object memory. This function may be analogous to aspects of human semantic memory (knowledge of objects, concepts, faces and words). To date, the status of perirhinal cortex has not specifically been investigated in patients with semantic deficits as seen in semantic dementia, the temporal lobe variant of frontotemporal dementia. High-resolution 3D magnetic resonance imaging was performed in subjects with semantic dementia and Alzheimerís disease (characterized in its early stages by selective episodic ... [more] |
| First CBU author: | Hodges, J.R. |
| Annual report number: | CBUAR 49 |
| Keywords: | semantic dementia, Alzheimers disease, volumetric MRI, entorhinal cortex |
# The role of the human medial temporal lobe in perception
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| CBU number: | 5825 |
| Authors: | LEE, A.C.H., Bussey, T.J., Murray, E.A., HODGES, J.R. & GRAHAM, K.S. |
| Reference: | Eleventh Annual Meeting of the Cognitive Neuroscience Society, 143 |
| Year of publication: | 2004 |
| Abstract text: | Animal studies suggest that the perirhinal cortex processes conjunctions of object features while the hippocampus plays a particular role in spatial processing. To date, however, neuropsychological studies have failed to support this view in humans. To investigate this discrepancy in the literature, a visual concurrent discrimination task was given to two patient groups who had suffered damage to the medial temporal lobe, the majority following anoxic episodes or encephalitis. One patient group had selective damage to the hippocampus bilaterally while a second group had more extensive lesions ... [more] |
| First CBU author: | Lee, A.C.H. |
| Annual report number: | CBUAR 48 |
| Keywords: | Conference Proceedings and Published Abstracts |
# Dissociating person-specific from general semantic knowledge: Roles of the left and right temporal lobes
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| CBU number: | 5706 |
| Authors: | Thompson, S.A., GRAHAM, K.S., Williams, G., PATTERSON, K., Kapur, N. & HODGES, J.R. |
| Reference: | Neuropsychologia, 42(3), 359-370 |
| Year of publication: | 2004 |
| Abstract text: | The cognitive architecture and neural underpinnings of different semantic domains remains highly controversial. We report two patients with focal temporal lobe atrophy who presented with contrasting and theoretically informative dissociations of person-specific versus general semantic knowledge. Subject J.P. showed severely impaired person-specific semantics, with relative preservation of knowledge about objects and animals, while subject M.A. exhibited the opposite pattern of performance (good knowledge of people in the context of impoverished general semantics). Voxel-based morphometric analysis ... [more] |
| First CBU author: | Hodges, J.R. |
| Annual report number: | CBUAR 48 |
# A Duck with Four Legs: Investigating the Structure of Conceptual Knowledge using Picture Drawing in Semantic Dementia
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| CBU number: | 5244 |
| Authors: | BOZEAT, S., Lambon Ralph, M.A., GRAHAM, K.S., PATTERSON, K., Wilkin, H., Rowland, J., ROGERS , T.T. & HODGES, J.R. |
| Reference: | Cognitive Neuropsychology 20(1), 27-47 |
| Year of publication: | 2003 |
| Abstract text: | These two studies analysed pictures of concrete concepts drawn by patients with semantic dementia to provide additional insight into the structure and internal representation of normal and degraded conceptual knowledge. A feature-based scoring scheme was constructed from analysis of drawings produced by normal participants to obtain a relatively objective measure that focussed on the content of the drawings and minimised the influence of drawing skill. In Study 1, in which six patients with semantic dementia were asked to produce drawings of concrete concepts from dictation of their names, ... [more] |
| First CBU author: | Hodges, J.R. |
| Annual report number: | CBUAR 47 |
# Viewpoint-Specific Scene Representations in Human Parahippocampal Cortex
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| CBU number: | 5570 |
| Authors: | Epstein, R., Graham, K.S. & Downing, P.E. |
| Reference: | Neuron, 37(5), 865-876 |
| Year of publication: | 2003 |
| Abstract text: | The ìparahippocampal place areaî (PPA) responds more strongly in functional magnetic resonance imaging (fMRI) to scenes than to faces, objects, or other visual stimuli. We used an event-related fMRI adaptation paradigm to test whether the PPA represents scenes in a viewpoint-specific or viewpoint-invariant manner. The PPA responded just as strongly to viewpoint changes that preserved intrinsic scene geometry as it did to complete scene changes, but less strongly to object changes within the scene. In contrast, lateral occipital cortex responded more strongly to object changes than to spatial ... [more] |
| First CBU author: | Graham, K.S. |
| Annual report number: | CBUAR 47 |